THE HEART PRELOAD AND AFTERLOAD INTERACTION AND RR INTERVALS UNDER HARD NORMOBARICHYPOXIA EXPOSURE IN HEALTHY YOUNG PERSONS



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Abstract

The study wThe left ventricular end diastolic pressure (EDP) fluctuations, specific peripheral vascular resistance (SPR) and cardiointervals (RR) on the respiration frequency under hard normobaric hypoxia (FIO2 = 0.1) were studied. 7 young men (volunteers) were subject to series of hard hypoxic exposures (6 weeks, every other day, intermittently by 6 × 5 min – FIO2 = 0.1). The hypoxic tests (HT1 and HT2) – FIO2 = 0.1, 15 min continuously) were performed before and after each series. SаO2 at the last 3 m of the tests on average was 82.5 % and 92.0 % respectively (Р < 0.05). During HT1 and HT2 (in comparison with inactivity) were increased: angle of max QRS vector (VQRS) in the frontal plain (68.5° ± 16.68 and 72.94° ± 15.32; 69.62° ± 22.4 and 74.45° ± 17.98 respectively), minutes blood flow (MBF) (6.41 ± 1.98 l/min and 6.87 ± 1.27 l/min; 5,27 ± 1,02 l/min and 5.67 ± 1.19 l/min respectively) (Р < 0.05). SPR was decreased too (27.39 ± 5.45 s.u. and 25.62 ± 4.96 s.u.; 30.59 ± 6.34 s.u. and 27.93 ± 5.77 s.u. respectively) (Р < 0.05). By means of transfer function analysis was shown that EDP fluctuations at HT2 significantly outpace by time (phase) the SPR and RR fluctuations on the respiration frequency (1.19 s ± 0.64 and 1.99 s ± 0.63 or 94.39° ± 43.3 and 125.4° ± 7.54; 1.65 s ± 1.28 and 2.22 s ± 0.87 or 101.4° ± 59.6 and 152.7° ± 21.26 respectively) (Р < 0.05). The increased oxyhemoglobin saturation is a trigger of artery wall smooth muscle relaxation mechanisms and this one is changes the background for beat to beat baroreflex realization on the respiration frequency.

About the authors

Aleksandr Sergeyevich Radchenko

St. Petersburg Research Institute of Physical Culture

Dr. Biol. Sci.

N. S. Borisenko

SRC “Arktika”, Kirov Military Medical Academy, Ministry of Defense of the Russian Federation

Junior Researcher, Dept. of Normal Physiology

A. I. Kalinichenko

St. Petersburg State Electrotechnical University

Dr. Techn. Sci., Professor, Dept. of Biotechnical Systems

Yu Yu Rodionova

St. Petersburg State Electrotechnical University

Ingeneer, Dept. of Biotechnical Systems

Yuriy Nikolayevich Korolev

Kirov Military Medical Academy, Ministry of Defense of the Russian Federation

PhD, Doсent, Dept. of Normal Physiology

Viktor Nikolayevich Golubev

Kirov Military Medical Academy, Ministry of Defense of the Russian Federation

Dr. Med. Sci., Professor, Dept. of Normal Physiology

O A Churganov

St. Petersburg Research Institute of Physical Culture

Dr. Ped, Sci., Professor, Deputy Director

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Copyright (c) 2013 Radchenko A.S., Borisenko N.S., Kalinichenko A.I., Rodionova Y.Y., Korolev Y.N., Golubev V.N., Churganov O.A.

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