Роль мобильных генетических элементов в формировании долговременной памяти

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В ряде экспериментальных исследований оспорено значение синаптической пластичности и доказана роль транспозонов в консолидации памяти. Это обусловлено cis-регуляторным влиянием активированных мобильных генетических элементов на экспрессию генов, а также инсерциями в новые локусы генома вблизи участвующих в функционировании головного мозга генов. Транскрипты и белки эндогенных ретровирусов транспортируются в области синапсов дендритов и передают информацию для изменения экспрессии генов в соседние клетки за счет формирования вирусоподобных частиц в составе везикул. Благодаря этому обеспечивается взаимосвязь синаптической пластичности с ядерным кодированием, поскольку мобильные генетические элементы являются также драйверами эпигенетической регуляции за счет взаимосвязи с произошедшими от них некодирующими РНК. Проведенный нами анализ научной литературы позволил выявить роль 17 возникших от транспозонов микроРНК в нормальном формировании памяти. При нейродегенеративных заболеваниях с нарушением памяти нами выявлено изменение экспрессии 44 произошедших от мобильных генетических элементов микроРНК. Это свидетельствует о возможностях таргетного воздействия на патологическую активацию транспозонов при нейродегенеративных болезнях для восстановления памяти с использованием микроРНК в качестве инструментов.

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Р. Н. Мустафин

Башкирский государственный медицинский университет

Автор, ответственный за переписку.
Email: ruji79@mail.ru
Россия, Уфа, 450008

Э. К. Хуснутдинова

Институт биохимии и генетики – обособленное структурное подразделение Уфимского федерального исследовательского центра Российской академии наук

Email: ruji79@mail.ru
Россия, Уфа, 450054

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