Comparative analysis of the creation of antidotes of organophosphorus toxic substances in Russia and abroad. The article is devoted to a comparative analysis of the creation of means of prevention and emergency treatment of organophosphorus poisoning in Russia and abroad. Antidote drugs traditionally used for intoxication with anticholinesterase poisons, as well as new-generation drugs developed abroad are considered. Attention is focused on compounds from the group of reversible inhibitors of cholinesterase, benzodiazepines, «bio-cleaners» as a means of preventing poisoning, on some new dosage forms of antidotes. Modern schemes of etiotropic and pathogenetic therapy of intoxication with organophosphorus toxic substances, based on the use of cholinesterase reactivators, cholinergic antagonists, benzodiazepines, are evaluated. The promise of using several agents, such as glutamate receptor blockers, for stopping toxic seizure syndrome, as well as drug combinations of various pharmacological groups, was noted - PDF (Russian)


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