Clinical and functional significance of extracellular microvesicles in the pathogenesis, diagnosis and treatment of sepsis

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Abstract

Multicenter studies are being conducted around the world aimed at finding new, effective diagnostic markers and therapeutic approaches to the diagnosis and treatment of systemic inflammatory response and sepsis. One of the promising directions is the use of extracellular microvesicles a heterogeneous group of membrane particles involved in cellular signaling at various levels and involved in many physiological and pathological processes as markers for verifying diagnosis, monitoring therapeutic response, predicting the course and outcome of the septic process. The review presents current data describing the diagnostic and therapeutic value of quantitative and qualitative studies of microvesicles in the treatment of patients with sepsis of various etiologies. The authors showed the features of biogenesis, morphofunctional characteristics of microvesicles, the pleiotropy of the effects of extracellular microparticles in septic conditions, in the pathogenesis of sepsis, septic shock, the pro-inflammatory and anti-inflammatory potential of microvesicles of various cellular origins, the implementation of which depends, among other things, on the stimulus that caused the formation of microparticles and the conditions of their functioning, state of the donor cell. The main directions for pathogenetic treatment of sepsis and septic shock using microvesicles are presented.

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About the authors

N. I. Bashilov

11469th Naval Clinical Hospital of the Russian Defense Ministry

Author for correspondence.
Email: ufo_139@mil.ru

майор медицинской службы

Russian Federation, Severomorsk, Murmansk region

Yu. N. Zakrevsky

11469th Naval Clinical Hospital of the Russian Defense Ministry; Murmansk Arctic University of the Ministry of Education and Science of the Russian Federation

Email: ufo_139@mil.ru

доктор медицинских наук, полковник медицинской службы запаса

Russian Federation, Severomorsk, Murmansk region; Murmansk

D. A. Arkhangelky

11469th Naval Clinical Hospital of the Russian Defense Ministry

Email: ufo_139@mil.ru

кандидат медицинских наук, полковник медицинской службы

Russian Federation, Severomorsk, Murmansk region

Y. V. Vysotsky

11469th Naval Clinical Hospital of the Russian Defense Ministry

Email: ufo_139@mil.ru

подполковник медицинской службы

Russian Federation, Severomorsk, Murmansk region

L. A. Mishanina

Murmansk Arctic University of the Ministry of Education and Science of the Russian Federation

Email: ufo_139@mil.ru

кандидат биологических наук

Russian Federation, Murmansk

O. G. Krivenko

Murmansk Arctic University of the Ministry of Education and Science of the Russian Federation

Email: ufo_139@mil.ru

кандидат медицинских наук

Russian Federation, Murmansk

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Copyright (c) 2024 Bashilov N.I., Zakrevsky Y.N., Arkhangelky D.A., Vysotsky Y.V., Mishanina L.A., Krivenko O.G.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.