Early diagnosis of dementia with the help of MR-morphometry in patients with Parkinson’s disease

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

54 patients with idiopathic Parkinson’s disease were examined. 1,5 Tesla MRI with T1 gradient-echoprotocol and following calculating by FreeSurfer software was performed. Dementia was revealed in 23 patients. Significant changes of different zones of brain-cortex were revealed in patients with Parkinson’s disease accompanied by dementia. Changes were revealed in the hemispheres, particularly in frontal, temporal and occipital lobes. Thickness of lingual medial occipitotemporal gyrus can be used as a criterion for dementia prognosis. Individual patient monitoring and cortex alteration evaluation allow prognosticating increasing risk of cognitive disorders development and prescribing proper therapy.

Full Text

Restricted Access

References

  1. Глозман, Ж.М., Артемьев ДВ, Дамулин И.В., Ковязина М.С. Возрастные особенности ней-ропсихологических расстройств при болезни Паркинсона // Вестн. Моск. универ. — 1994. — № 3. - С. 25-36.
  2. Захаров В.В., Ярославцева Н.В., Яхно H.H. Когнитивные нарушения при болезни Паркинсона // Неврол. журн. — 2003. — Т. 8, № 2. — С. 11-16.
  3. Корсакова Н.К., Москвичюте Л.И. Подкорковые структуры мозга и психические процессы. — М.: Изд-во МГУ, 1985. — 119 с.
  4. Левин, О.С., Федорова Н.В., Шток В.Н. Дифференциальная диагностика паркинсонизма // Журн. неврол. и психиатр. им. С.С.Корсакова. — 2003. — № 2. — С. 54—60.
  5. Литвиненко И.В. Болезнь Паркинсона. — М: Миклош, 2006. — 120 с.
  6. Aarsland D., Andersen К., Larsen J.P. et al. Prevalence and characteristics of dementia in Parkinson’s disease: an 8-year prospective study // Arch. Neurol. — 2003. — Vol. 60. — P. 387—392.
  7. Chui H.C., Mortimer J.A., Slager U. et al. Pathologic correlates of dementia in Parkinson’s disease // Arch. Neurol. — 1986. — Vol. 43. — P. 991—995.
  8. Dubois B., Slachevski A., Litvan I. et al. The FAB: A frontal assessment battery at bedside // Neurology. — 2000. — Vol. 55, N 11. — P. 1621—1626.
  9. Emre M., Aarsland D., Albanese A. et al. Rivastigmine for dementia associated with Parkinson’s disease // New Eng. J. Med. — 2004. — Vol. 351. — P. 2509—2518.
  10. Folstein M.F. Folstein S.E., McHugh P.R. «Mini-mental state». A practical method for grading the cognitive state of patients for the clinician // J. Psychiatr. Res. — 1975. — Vol. 12, N 3. — P. 189—198.
  11. Lyoo C.H., Ryu M.S., Lee M.S. Topographical distribution of cerebral cortical thinning in patients with mild Parkinson’s disease without dementia // Mov. Disord. — 2010. — Vol. 25, N 4. — P. 496—499.
  12. Owen A.M., James M., Leigh P.N. et al. Fronto striatal cognitive deficits at different stages of Parkinson’s disease // Brain. — 1992. — Vol. 115. — P. 1727—1751.
  13. Saint-Cyr J.A., Taylor A.E., Nikolson K. Behaviour and Basal ganglia. In: Behavioral Neurology of Movement Disorder / W.J.Weiner, A.E.Lang (eds) // Adv. Neurol. — 1995. — Vol. 65. — P. 1—29.
  14. Sunderland T., Hill J.L., Mellov A.M. et al. Clock drawing in Alzheimer’s disease. A novel measure of dementia severity // J. Am. Geriatr. Soc. — 1989. — Vol. 37, N 8. — P. 725—729.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2013 Trufanov A.G., Odinak M.M., Litvinenko I.V., Rezvantsev M.V., Voronkov L.V.



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies