Early diagnosis of dementia with the help of MR-morphometry in patients with Parkinson’s disease


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Abstract

54 patients with idiopathic Parkinson’s disease were examined. 1,5 Tesla MRI with T1 gradient-echoprotocol and following calculating by FreeSurfer software was performed. Dementia was revealed in 23 patients. Significant changes of different zones of brain-cortex were revealed in patients with Parkinson’s disease accompanied by dementia. Changes were revealed in the hemispheres, particularly in frontal, temporal and occipital lobes. Thickness of lingual medial occipitotemporal gyrus can be used as a criterion for dementia prognosis. Individual patient monitoring and cortex alteration evaluation allow prognosticating increasing risk of cognitive disorders development and prescribing proper therapy.

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Copyright (c) 2013 Trufanov A.G., Odinak M.M., Litvinenko I.V., Rezvantsev M.V., Voronkov L.V.


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