Phagoprophylaxis and bacteriophage treatment of surgical infections

Abstract

Due to the constant formation of the antibiotic resistance ofpathogens the search for alternative and synergistic ways antibiotic prophylaxis and treatment of infectious complications of wounds becomes current. This article is devoted to various aspects of the use of bacteriophages. The historical background of these drugs, and the biological properties are given. The authors assessed the capabilities of phage preparations for treatment and prevention of infectious complications of wounds. It is noted that for these purposes most suitable preparations containing several phages active against major pathogens of surgical infections. The authors assessed the properties piobacteriofag polyvalent «Sekstafag» in vitro and its efficacy in clinical practice. Based on analysis of published data and own investigations we may conclude that the of using piobacteriofag for the prevention and treatment of infectious complications of wounds may be perspective.