The military-biological aspect of the human genotypes study on the example of COVID-19

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The purpose of the study was to evaluate human genotype data as a basis for biological warfare, so the authors used materials from open scientific publications. Epidemiology, clinic, and outcomes were analyzed using the example of COVID-19 in people of different genotypes. The possibilities of reverse genetics for the construction of coronaviruses with modified specificity and «new functions» are considered. The authors have established that the severity of the course of COVID-19 depends mainly on the genes that determine the factors of the host’s immune response to the virus; while the different susceptibility of people to SARS-CoV-2 is mainly associated with variants of genes encoding surface receptors and having relation to the initial stage of infection.

作者简介

M. Supotnitskiy

27th Research Center, Ministry of Defense of the Russian Federation

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Email: 27nc_1@mil.ru

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俄罗斯联邦, Moscow

参考

  1. Anastassopoulou C., Gkizarioti Z., Patrinos G.P., Tsakris A. Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity // Hum. Genomics. – 2020. – Vol. 14, N 1. – P. 40. https://doi.org/10.1186/s40246-020-00290-4
  2. Cheng H., Wang Y., Wang G.-Q. Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19 // J. Med. Virol. – 2020. – Vol. 92, N 7. – P. 726–730. https://doi.org/10.1002/jmv.25785
  3. Elhabyan A., Elyaacoub S., Sanad T. et al. The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review // Virus Res. – 2020. – Vol. 289. – P. 198163. https://doi.org/10.1016/j.virusres. 2020.198163
  4. Hou Y., Zhao J., Martin W. et al. New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis // BMC Med. – 2020. – Vol. 18. – P. 216. https://doi.org/10.1186/s12916-020-01673-z
  5. Millett G.A., Jones A.T., Benkeser D. et al. Assessing Differential Impacts of COVID-19 on Black Communities // Ann. Epidemiol. – 2020. – Vol. 44. https://doi.org/10.1016j.annepidem. 2020.05.003
  6. Pana D., Szec S., Minhasc J.S. et al. The impact of ethnicity on clinical outcomes in COVID-19: A systematic review // Clin. Medicine. – 2020. – Vol. 23. – P. 100404. https://doi.org/10.1016/j.eclinm.2020.100404
  7. Pickard A., Calverley B., Chang J. et al. Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells // PLoS Pathog. – 2021. – Vol. 17, N 9. – e1009840. https://doi.org/10.1371/journal.ppat.1009840
  8. Ren W., Zhu Y., Lan J. et al. Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection // J. Virol. – 2022. – Vol. 96, N 1. – e01492-21. https://doi.org/10.1128/JVI.01492-21
  9. Rihn S., Merits A., Bakshi S. et al. A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research // PLoS Biol. – 2021. – Vol. 19, N 2. – e3001091. https://doi.org/10.1371/journal. pbio.3001091
  10. Thao T.T.N., Labroussaa F., Thiel V. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform // Nature. – 2020. – Vol. 582. – P. 561–565. https://doi.org/10.1038/s41586-020-2294-9
  11. Vepa A., Bae J.P., Ahmed F. et al. COVID-19 and ethnicity: A novel pathophysiological role for inflammation // Diabetes Metab. – 2020. – Vol. 14, N 5. – P. 1043–1051. https://doi.org/10.1016/j.dsx.2020.06.056
  12. Xie X., Lokugamage K.G., Zhang X. et al. Engineering SARS-CoV-2 using a reverse genetic system // Nat. Protoc. – 2021. – Vol. 16, N 3. – P. 1761–1784. https://doi. org/10.1038/s41596-021-00491-8
  13. Xie X., Muruato A., Lokugamage K.G. et al. An infectious cDNA clone of SARS-CoV-2 // Cell. Host. Microbe. – 2020. – Vol. 27, N 5. – P. 841–848. https://doi.org/10.1016/j.chom. 2020.04.004
  14. Ye Ch., Chiem K., Park J.-G. et al. Rescue of SARS-CoV-2 from a single bacterial artificial chromosome // mBio. – 2020. – Vol. 11, N 5. – e02168-20. https://doi.org/10.1128/ mBio.02168-20

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