THE EVALUATION OF RISK OF DEVELOPMENT AND COURSE OF BRONCHIAL ASTHMA ON THE BASIS OF POLYMORPHISM OF GENE TNFA

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Abstract

The bronchial asthma is one of the most widespread multi-factorial diseases developing in interaction of environmental and genetic factors. The purpose of this study was to analyze association of polymorphism of gene TNFA with risk of development of bronchial asthma considering clinical form of disease. The polymerase chain reaction technique was applied to analyze polymorphic locus rs1800629 of gene TNFA in patients with bronchial asthma (n=133) and control group (n=195). The analysis of rate of polymorphism of gene TNFA established reliable increasing of rate of allele A in group of patients with bronchial asthma as compared with control sample. According the coefficient of chances ratio, the risk of development of bronchial asthma if there is allele A of polymorphic locus rs1800629 of gene TNFA increases more than twice (OR=2,53; 95% CI 1,45-4,43). At that, various firms of bronchial asthma have specific features in distribution of rates of genotypes of polymorphic locus rs1800629 of gene TNFA. It is demonstrated that among agents of genotypes GA of polymorphic modification of rs1800629 of gene TNFA patients with mixed form of bronchial asthma were found more frequently than among agents of genotypes GG. The obtained results provide ground to suppose that polymorphic modification of rs1800629 of gene TNFA shows certain damaging effect under various clinical forms of bronchial asthma.

About the authors

G. F. Mukhammadieva

Ufa Research Institute of Labor and Human Ecology

Author for correspondence.
Email: ufniimt@mail.r
Russian Federation

T. G. Kutlina

Ufa Research Institute of Labor and Human Ecology

Russian Federation

D. O. Karimov

Ufa Research Institute of Labor and Human Ecology

Russian Federation

Ya. V. Valova

Ufa Research Institute of Labor and Human Ecology; Bashkir State University

Russian Federation

P. V. Serebryakov

The F.F. Erisman Federal Research Сenter of Hygiene

Russian Federation

A. V. Melent’Ev

The F.F. Erisman Federal Research Сenter of Hygiene

Russian Federation

A. B. Bakirov

Ufa Research Institute of Labor and Human Ecology

Russian Federation

A. U. Shagalina

Ufa Research Institute of Labor and Human Ecology

Russian Federation

E. F. Idiyatullina

Ufa Research Institute of Labor and Human Ecology

Russian Federation

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Copyright (c) 2020 Mukhammadieva G.F., Kutlina T.G., Karimov D.O., Valova Y.V., Serebryakov P.V., Melent’Ev A.V., Bakirov A.B., Shagalina A.U., Idiyatullina E.F.

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