Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation
- 作者: Garaev Т.М.1, Yudin I.I.1, Breslav N.V.1, Savochkina Т.Е.1, Krepkaya А.S.1, Grebennikova Т.V.1, Nikiforova S.Е.2, Myshletsov I.I.2, Avdeeva V.V.2, Malinina Е.А.2
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隶属关系:
- National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
- Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
- 期: 卷 69, 编号 5 (2024)
- 页面: 736-742
- 栏目: КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ
- URL: https://journals.eco-vector.com/0044-457X/article/view/666540
- DOI: https://doi.org/10.31857/S0044457X24050113
- EDN: https://elibrary.ru/YEWODX
- ID: 666540
如何引用文章
详细
This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.
作者简介
Т. Garaev
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
I. Yudin
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
N. Breslav
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
Т. Savochkina
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
А. Krepkaya
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
Т. Grebennikova
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
S. Nikiforova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
I. Myshletsov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
V. Avdeeva
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
Е. Malinina
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow
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