Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

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This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

作者简介

Т. Garaev

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

I. Yudin

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

N. Breslav

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

Т. Savochkina

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

А. Krepkaya

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

Т. Grebennikova

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

S. Nikiforova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

I. Myshletsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

V. Avdeeva

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

Е. Malinina

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
俄罗斯联邦, Moscow

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