Nitro-Substituted Pyridinimine Complexes of Pd(II): Synthesis and Inhibition of MAO-B ex vivo

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Abstract

The first ever synthesis of complexes [PdLCl2] (I) and [PdLBr2] (II) was successfully achieved,
where L = 2,6-dimethyl-4-nitro-N-(pyridin-2-ylmethylildene)aniline, a ligand with a purported ability to
inhibit monoamine oxidase B (MAO-B). To gain insight into the molecular structure of complexes I
and II, as well as the ligand precursor 2,6-dimethyl-4-nitroaniline L4 (CIF files CCDC nos. 2255106 (I),
2255105 (II), 2255103 (L), 2255104 (L4)), X-ray diffraction analysis was utilized. Complex I underwent further
characterization to determine its stability, solubility, and lipophilicity. Cytotoxicity studies of substances
L, I, and II on human embryonic kidney cell line HEK-293 showed no evidence of cytotoxic activity. To evaluate
the inhibitory activity of new substances L, I, and II as well as established substances III−IX, selegiline,
and rasagiline, ex vivo studies were conducted, establishing a structure/activity relationship.

About the authors

M. S. Denisov

Institute of Technical Chemistry of Ural Branch of the RAS, Perm, Russia

Email: m189@mail.ru
Россия, Пермь

Yu. A. Beloglazova

Institute of Technical Chemistry of Ural Branch of the RAS, Perm, Russia

Author for correspondence.
Email: m189@mail.ru
Россия, Пермь

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