Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline
- 作者: Ermakova E.A.1, Golubeva Y.A.1, Smirnova K.S.1, Klyushova L.S.2, El’tsov I.V.3, Lider E.V.1
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隶属关系:
- Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
- Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia
- Novosibirsk National Research State University, Novosibirsk, Russia
- 期: 卷 49, 编号 9 (2023)
- 页面: 582-589
- 栏目: Articles
- URL: https://journals.eco-vector.com/0132-344X/article/view/667484
- DOI: https://doi.org/10.31857/S0132344X22600631
- EDN: https://elibrary.ru/WAENNY
- ID: 667484
如何引用文章
详细
The complex [Zn(Phen)(H2O)L2] (I), where HL is 5-benzyltetrazole, Phen is 1,10-phenanthroline,
was synthesized. The compound was characterized by standard physicochemical methods (elemental
analysis, powder X-ray diffraction, IR spectroscopy). According to X-ray diffraction data (CCDC no.
2220597), zinc coordination environment in the crystal structure of I corresponds to a distorted trigonal
bipyramid. The ligand HL is monodentate and is coordinated via tetrazolate ring nitrogen. The stability of
complex I was studied by NMR spectroscopy in DMSO. The cytotoxic properties of the compound were
assessed against HepG-2 (hepatocellular carcinoma) and MRC-5 (noncancerous human fibroblasts) cells.
Complex I exhibits weak cytotoxic properties in the studied concentration range (1–100 μM).
关键词
作者简介
E. Ermakova
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
Email: lisalider@ngs.ru
Россия, Новосибирск
Yu. Golubeva
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
Email: lisalider@ngs.ru
Россия, Новосибирск
K. Smirnova
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
Email: lisalider@ngs.ru
Россия, Новосибирск
L. Klyushova
Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine,Novosibirsk, Russia
Email: lisalider@ngs.ru
Россия, Новосибирск
I. El’tsov
Novosibirsk National Research State University, Novosibirsk, Russia
Email: lisalider@ngs.ru
Россия, Новосибирск
E. Lider
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
编辑信件的主要联系方式.
Email: lisalider@ngs.ru
Россия, Новосибирск
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