Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline

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The complex [Zn(Phen)(H2O)L2] (I), where HL is 5-benzyltetrazole, Phen is 1,10-phenanthroline,
was synthesized. The compound was characterized by standard physicochemical methods (elemental
analysis, powder X-ray diffraction, IR spectroscopy). According to X-ray diffraction data (CCDC no.
2220597), zinc coordination environment in the crystal structure of I corresponds to a distorted trigonal
bipyramid. The ligand HL is monodentate and is coordinated via tetrazolate ring nitrogen. The stability of
complex I was studied by NMR spectroscopy in DMSO. The cytotoxic properties of the compound were
assessed against HepG-2 (hepatocellular carcinoma) and MRC-5 (noncancerous human fibroblasts) cells.
Complex I exhibits weak cytotoxic properties in the studied concentration range (1–100 μM).

作者简介

E. Ermakova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

Yu. Golubeva

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

K. Smirnova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

L. Klyushova

Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine,
Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

I. El’tsov

Novosibirsk National Research State University, Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

E. Lider

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

编辑信件的主要联系方式.
Email: lisalider@ngs.ru
Россия, Новосибирск

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版权所有 © Е.А. Ермакова, Ю.А. Голубева, К.С. Смирнова, Л.С. Клюшова, И.В. Ельцов, Е.В. Лидер, 2023