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Study of the Reduction of Cobalt(III) Complexes by In Situ NMR Spectroscopy
- Authors: Nikovskii I.A.1, Babakina D.A.2, Denisov G.L.1,3, Nelyubina Y.V.1,3, Khakina E.A.1,3
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Affiliations:
- Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
- Mendeleev University of Chemical Technology of Russia, Moscow, Russia
- Bauman State Technical University (National Research University), Moscow, Russia
- Issue: Vol 49, No 1 (2023)
- Pages: 27-35
- Section: Articles
- URL: https://journals.eco-vector.com/0132-344X/article/view/667536
- DOI: https://doi.org/10.31857/S0132344X22700037
- EDN: https://elibrary.ru/ERVRRS
- ID: 667536
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Abstract
An approach for monitoring the redox activation of drug delivery in cobalt(III) complexes by in situ NMR spectroscopy is proposed. The reduction of the heteroleptic cobalt(III) complexes containing the 6,7-dihydroxycoumarin molecule applied as a model drug is studied using the proposed approach. The replacement of the bipyridine ligand in the cobalt(III) complex by phenanthroline considerably increases the redox-activated release rate of the drug.
About the authors
I. A. Nikovskii
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
Email: khakina90@ineos.ac.ru
Россия, Москва
D. A. Babakina
Mendeleev University of Chemical Technology of Russia, Moscow, Russia
Email: khakina90@ineos.ac.ru
Россия, Москва
G. L. Denisov
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia; Bauman State Technical University (National Research University), Moscow, Russia
Email: khakina90@ineos.ac.ru
Россия, Москва; Россия, Москва
Yu. V. Nelyubina
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia; Bauman State Technical University (National Research University), Moscow, Russia
Email: khakina90@ineos.ac.ru
Россия, Москва; Россия, Москва
E. A. Khakina
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia; Bauman State Technical University (National Research University), Moscow, Russia
Author for correspondence.
Email: khakina90@ineos.ac.ru
Россия, Москва; Россия, Москва
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