Leptin resistance: possible mechanisms of formation and potential possibilities of correction


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Abstract

Leptin is a peptide hormone derived from adipocytes that contributes to the homeostatic regulation of energy balance and metabolism (primarily fat) through the humoral and nerve pathways. Leptin acts on neurons in specific areas of the brain, such as the hypothalamus, hippocampus, and brainstem, to regulate food Intake, thermogenesis, energy expenditure, and lipid and glucose metabolism. A biomarker of leptin resistance Is abnormally elevated levels of circulating leptin, which is common In obese people. Leptin resistance is defined as a decreased sensitivity or Inability of the brain to respond to leptin, which is accompanied by impaired ability of leptin to suppress appetite or increase energy expenditure, which ultimately leads to overweight, obesity, other metabolic disorders and cardiovascular disease. Leptin resistance is an Important clinical problem; however, no dmgs have yet been found to correct It, and this is primarily due to significant gaps in the pathophysiology of leptin. At the same time, more and more data are emerging on new mechanisms of leptin resistance. Here, we have combined data from studies related to leptin resistance and associated diseases in order to better understand the physiology and pathophysiology of leptin, and also described new strategies for the treatment of lipid disorders, in particular obesity.

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About the authors

A. A Borodkina

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases; State Autonomous institution of healthcare «Kemerovo regional clinical hospital

O. V Gruzdeva

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University

E. E Bychkova

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases

G. P Makshanova

Kemerovo State Medical University

E. I Palicheva

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University

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