Sensitization to Aspergillus spp. in patients with asthma


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Abstract

Objective: To evaluate the effect of sensitization to Aspergillus spp. the severity and level of control of asthma. Materials and methods: 275 patients with allergic asthma were examined. The levels of total IgE and specific IgE to aeroallergens were determined in the blood serum by the enzyme immunoassay method. Anamnesis, objective examination, and spirometry data were analyzed to assess the reversibility of the obstruction. The Russian-language version of the questionnaire was used: the Asthma Control Test (Asthma Control Test) The data obtained were processed using the Statistica 10 software system. Results: In patients with asthma with sensitization to Aspergillus spp. the course of the disease was uncontrolled, there were low indicators of external respiratory function, a greater number of exacerbations, a higher need for drugs for basic therapy than in the group of patients with asthma without sensitization to Aspergillus spp. (p<0.05), which suggests a more severe course of the disease. The most significant factors that negatively affect the achievement of a controlled course of asthma are: sensitization to Aspergillus spp., fixed airway obstruction, and living in rooms affected by mold fungi. Conclusion: Sensitisation to Aspergillus spp. associated with severe, uncontrolled asthma.

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About the authors

Ya. I Kozlova

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Associate Professor, Candidate of Medical Sciences Saint Petersburg

A. E Uchevatkina

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Candidate of Medical Sciences Saint Petersburg

L. V Filippova

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Candidate of Medical Sciences Saint Petersburg

O. V Aak

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Candidate of Chemical Sciences Saint Petersburg

V. D. Kuznetsov

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Saint Petersburg

E. V Frolova

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Candidate of Medical Sciences; Professor Saint Petersburg

N. V Vasilyeva

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Biol. Dr.; Professor Saint Petersburg

N. N Klimko

North-Western State Medical University named after I.I. Mechnikov

Email: kozlova510@mail.ru
Professor; MD Saint Petersburg

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