Risk for folate-dependent congenital malformations upon preconception exposure to medicines: the impact of ABCB1 gene polymorphism
- Authors: Pikuza T.V1, Chilova R.A1, Sokova E.A1,2, Kazakov R.E2, Zhukova E.V1, Trifonova N.S1, Shikh E.V1, Mazur S.I3
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
- Research Center for Examination of Medical Products, Ministry of Health of Russia
- OOO “Fertimed”
- Issue: Vol 33, No 4 (2022)
- Pages: 79-84
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/114600
- DOI: https://doi.org/10.29296/25877305-2022-04-12
- ID: 114600
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Open Access
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Abstract
The results of numerous studies demonstrate the heterogeneity of the causes of congenital malformations (CMs) (genetic, chromosomal, teratogenic, etc.), although the nature of CMs remains unknown and is multifactorial in a significant proportion (65-70%) of cases. At least 2-3% of all CMs are known to be associated with the use of drugs. The paper gives the results of the authors’ own study evaluating the impact of ABCB1 gene polymorphism on the risk of CMs in the Russian population of pregnant women.
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About the authors
T. V Pikuza
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
R. A Chilova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
E. A Sokova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Research Center for Examination of Medical Products, Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат медицинских наук, доцент
R. E Kazakov
Research Center for Examination of Medical Products, Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат биологических наук
E. V Zhukova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат медицинских наук
N. S Trifonova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат медицинских наук
E. V Shikh
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
доктор медицинских наук, профессор
S. I Mazur
OOO “Fertimed”
Author for correspondence.
Email: rtchilova@gmail.com
References
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