Risk for folate-dependent congenital malformations upon preconception exposure to medicines: the impact of ABCB1 gene polymorphism
- 作者: Pikuza T.V1, Chilova R.A1, Sokova E.A1,2, Kazakov R.E2, Zhukova E.V1, Trifonova N.S1, Shikh E.V1, Mazur S.I3
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隶属关系:
- I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
- Research Center for Examination of Medical Products, Ministry of Health of Russia
- OOO “Fertimed”
- 期: 卷 33, 编号 4 (2022)
- 页面: 79-84
- 栏目: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/114600
- DOI: https://doi.org/10.29296/25877305-2022-04-12
- ID: 114600
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详细
The results of numerous studies demonstrate the heterogeneity of the causes of congenital malformations (CMs) (genetic, chromosomal, teratogenic, etc.), although the nature of CMs remains unknown and is multifactorial in a significant proportion (65-70%) of cases. At least 2-3% of all CMs are known to be associated with the use of drugs. The paper gives the results of the authors’ own study evaluating the impact of ABCB1 gene polymorphism on the risk of CMs in the Russian population of pregnant women.
全文:
作者简介
T. Pikuza
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
R. Chilova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
E. Sokova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Research Center for Examination of Medical Products, Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат медицинских наук, доцент
R. Kazakov
Research Center for Examination of Medical Products, Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат биологических наук
E. Zhukova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат медицинских наук
N. Trifonova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
кандидат медицинских наук
E. Shikh
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: rtchilova@gmail.com
доктор медицинских наук, профессор
S. Mazur
OOO “Fertimed”
编辑信件的主要联系方式.
Email: rtchilova@gmail.com
参考
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- Зюзикова З.С., Волеводз Н.Н., Шестакова М.В. и др. Анализ структуры и частоты врожденных пороков развития у детей, рожденных с помощью вспомогательных репродуктивных технологий. Вопросы гинекологии, акушерства и перинатологии. 2019; 18 (6): 85-91. doi: 10.20953/1726-1678-2019-6-85-91
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- Wang C., Li H., Luo C. et al. The effect of maternal obesity on the expression and functionality of placental P-glycoprotein: Implications in the individualized transplacental digoxin treatment for fetal heart failure. Placenta. 2015; 36 (10): 1138-47. DOI: 10.1016/j. placenta.2015.08.007
- Toufaily M.H., Westgate M.N., Lin A.E. et al. Causes of Congenital Malformations. Birth Defects Res. 2018; 110 (2): 87-91. doi: 10.1002/bdr2.1105
- Frigerio B., Bizzoni C., Jansen G. et al. Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases. J Exp Clin Cancer Res. 2019; 38 (1): 125. doi: 10.1186/s13046-019-1123-1
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