The role of metformin in the treatment of elderly patients with type 2 diabetes mellitus and coronavirus infection

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Abstract

Since December 2019, the world has been gripped by the coronavirus infection (COVID-19) pandemic caused by SARS-CoV-2. At the end of January 2022, there were 356,028,523 infections and 5,613,346 deaths with a significant proportion of deaths occurring in elderly and senile patients. Numerous studies have shown that the majority of elderly patients who experienced COVID-19 had comorbidities (diabetes mellitus (DM), hypertensive disease, and cardiovascular disease). About 10-20% of older patients with COVID-19 had generally DM. The investigations conducted by US scientists indicate that people with obesity and type 2 diabetes (T2D) are more vulnerable to coronavirus infection. Thus, elderly patients with DM need more attention to both the prevention during the pandemic and outpatient and inpatient treatment in the presence of COVID-19. The antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties of metformin allow it to be considered as an additional therapy in elderly patients with T2D and COVID-19.

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About the authors

O. N. Belousova

Belgorod State National Research University

Author for correspondence.
Email: belousova_on@bsu.edu.ru

доктор медицинских наук

M. V. Chupakha

Belgorod State National Research University

Email: belousova_on@bsu.edu.ru

A. S. Rukavishnikov

N.K. Orlov Dolinsk Central District Hospital

Email: belousova_on@bsu.edu.ru

Candidate of Medical Sciences

S. G. Lenkin

Medical center «Paid KVD»

Email: belousova_on@bsu.edu.ru

Candidate of Medical Sciences

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