RESTORATION OF FEMALE SEXUAL FUNCTION IN THE REHABILITATION PROGRAM AFTER SURGICAL TREATMENT FOR ENDOMETRIAL CANCER

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To evaluate the effectiveness of the developed comprehensive personalized rehabilitation program in restoring sexual function in female patients after radical treatment for endometrial cancer (EC). Subjects and methods. The investigation involved 61 reproductive-aged patients with histologically verified endometrioid carcinoma after radical surgery. The women were randomized into 2 groups: 1) 29 patients treated with an active rehabilitation through a comprehensive restorative program; 2) 32 patients treated with a passive rehabilitation, whose management corresponded to clinical recommendations. Follow-ups were performed at 1 week and 3, 6, and 12 months after surgery. Each visit included clinical examination and assessment of sexual function, by using the FSFI questionnaire. Results. Statistically significant differences between the groups were obtained after 6 and 12 months. At the end of the study, the total FSFI score showed an almost complete recovery of sexual function in the active rehabilitation group (a total FSFI score of 24.93±2.86), unlike the comparison group (a total FSFI score of 13.39±2.55; p < 0.001). Conclusion. Comprehensive personalized rehabilitation mitigates the consequences of radical surgery in patients with EC, contributing to the restoration of sexual function within 1 year after surgery.

全文:

受限制的访问

作者简介

L. Sandzhieva

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: antoninasolopova@yandex.ru
俄罗斯联邦,

D. Blinov

Institute of Preventive and Social Medicine; Lapino Clinical Hospital, Village of Lapino; F.P. Gaaz Moscow Sociomedical Institute

Email: antoninasolopova@yandex.ru

Candidate of Medical Sciences

俄罗斯联邦,

A. Solopova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: antoninasolopova@yandex.ru

доктор медицинских наук, профессор

俄罗斯联邦,

E. Achkasov

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: antoninasolopova@yandex.ru

Professor, MD

俄罗斯联邦,

V. Galkin

City Clinical Oncology Hospital One, Moscow Healthcare Department

Email: antoninasolopova@yandex.ru

Professor, MD

俄罗斯联邦,

D. Korabelnikov

F.P. Gaaz Moscow Sociomedical Institute

Email: antoninasolopova@yandex.ru

Professor, MD

俄罗斯联邦,

D. Petrenko

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

编辑信件的主要联系方式.
Email: antoninasolopova@yandex.ru
俄罗斯联邦,

参考

  1. Sung H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021; 71 (3): 209-49. doi: 10.3322/caac.21660
  2. Fernandez-Montoli M.E., Sabadell J., Contreras-Perez N.A. Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol. Adv Ther. 2021; 38 (5): 2717-31. doi: 10.1007/s12325-021-01693-y
  3. Каприн А.Д., Старинский В.В., Шахзадова А.О. Злокачественные новообразования в России в 2020 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена -филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2021; c. 252.
  4. Солопова А.Г., Блинов Д.В., Бегович Е., и др. Неврологические расстройства после гистерэктомии: от патогенеза к клинике. Эпилепсия и пароксизмальные состояния. 2022; 14 (1): 54-64. doi: 10.17749/2077-8333/epi.par.con.2022.115
  5. Власина А.Ю., Идрисова Л.Э., Солопова А.Г. и др. Реабилитация онкогинекологических больных после противоопухолевой терапии: пути решения. Акушерство, Гинекология и Репродукция. 2020; 14 (1): 44-55. doi: 10.17749/2313-7347.2020.14.1.44-55
  6. Son J., Carr C., Yao M. et al. Endometrial cancer in young women: prognostic factors and treatment outcomes in women aged №40 years.Int J Gynecol Cancer. 2020; 30 (5): 631-9. doi: 10.1136/ijgc-2019-001105
  7. Natavio K.M.A., Billod J.A. Sexual dysfunction among patients with endometrial cancer at a tertiary training public institution: A cross-sectional study. Philippine J Obstet Gynecol. 2021; 45 (6): 608-12. doi: 10.1097/IGC.0000000000000905
  8. Karatajli V., Can B., Qakir I. et al. Life quality of endometrioid endometrial cancer survivors: a cross-sectional study. J Obstet Gynaecol. 2021; 41 (4): 621-5. doi: 10.1080/01443615.2020.1787969
  9. Rizzuto I., Oehler M.K., Lalondrelle S. Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers. Clin Oncol. 2021; 33 (9): 602-7. DOI: 10.1016/j. clon.2021.07.003
  10. Smith S.R., Zheng J.Y., Silver J. et al. Cancer rehabilitation as an essential component of quality care and survivorship from an international perspective. Disabil Rehabil. 2018; 42 (1): 8-13. doi: 10.1080/09638288.2018.1514662
  11. Рак тела матки и саркомы матки. Клинические рекомендации. Минздрав России. 2020. Электронный ресурс. URL: https://cr.minzdrav.gov.ru/recomend/460_3
  12. Власина А.Ю., Солопова А.Г., Сон Е.А. и др. Психоэмоциональное благополучие и сексуальная функция больных пограничными опухолями яичников. Акушерство, Гинекология и Репродукция. 2020; 14 (5): 551-67. doi: 10.17749/2313-7347/ob.gyn. rep.2020.147
  13. Wiegel M., Meston C., Rosen R. The female sexual function index (FSFI): crossvalidation and development of clinical cutoff scores. J Sex Marital Ther. 2005; 31 (1): 1-20. doi: 10.1080/00926230590475206
  14. Smith T., Kingsberg S.A., Faubion S. Sexual dysfunction in female cancer survivors: Addressing the problems and the remedies. Maturitas. 2022; 165: 52-7. DOI: 10.1016/j. maturitas.2022.07.010
  15. Hosseini S.E., Ilkhani M., Rohani C. et al. Prevalence of sexual dysfunction in women with cancer: A systematic review and meta-analysis.Int J Reprod BioMed. 2022; 20: 1-12. doi: 10.18502/ijrm.v20i1.10
  16. Gao J., Tian J., Lv Y. et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci. 2009; 100 (3): 389-95. doi: 10.1111/j.1349-7006.2008.01053.x
  17. Onujiogu N., Johnson, T., Seo. et al. Survivors of endometrial cancer: who is at risk for sexual dysfunction? Gynecol Oncol. 2011; 123 (2): 356-9. doi: 10.1016/j.ygyno.2011.07.035
  18. Блинов Д.В., Солопова А.Г, Плутницкий А.Н. и др. Организация здравоохранения в сфере реабилитации больных с онкологическими заболеваниями репродуктивной системы. ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология. 2022; 15 (1): 119-30. doi: 10.17749/2070-4909/ farmakoekonomika.2022.132
  19. Солопова А.Г., Блинов Д.В., Демьянов С.В. и др. Эпигенетические аспекты в реабилитации онкологических больных женщин. ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология. 2022; 15 (2): 294-303. doi: 10.17749/2070-4909/farmakoekonomika.2022.141

补充文件

附件文件
动作
1. JATS XML
2. Study design

下载 (185KB)

版权所有 © Russkiy Vrach Publishing House, 2022