Localized prostate cancer: transcriptional mechanisms of early recurrence
- 作者: Bova F.1
-
隶属关系:
- Rostov Research Institute of Oncology, Ministry of Health of Russia
- 期: 卷 30, 编号 2 (2019)
- 页面: 41-43
- 栏目: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115168
- DOI: https://doi.org/10.29296/25877305-2019-02-07
- ID: 115168
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
The author shows that in localized prostate cancer, one of the mechanisms of activation of the transcriptional potential of cancer cells and early recurrence of the disease is to increase the expression of the HIFIa and NF-kB genes in glandular tissue.
全文:
作者简介
F. Bova
Rostov Research Institute of Oncology, Ministry of Health of Russia
Email: alald@inbox.ru
Candidate of Medical Sciences Rostov-on-Don
参考
- Кит О.И., Водолажский Д.И., Кутилин Д.С. и др. Относительная копийность апоптоз-регулирующих генов как показатель малигнизации тканей желудка // Успехи современного естествознания. - 2015; 3: 40-5
- Zarrei M., MacDonald J., Merico D. et al. A copy number variation map of the human genome // Nature Reviews Genetics. - 2015; 16: 172-83.
- Iommarini L., Ghelli A., Gasparre G. и др. Mitochondrial metabolism and energy sensing in tumor progression // Biochim Biophys Acta. - 2017; 1858: 582-90.
- Jung S., Yang W., Kim J. et al. Reactive oxygen species stabilize hypoxiainducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells // Carcinogenesis. -2008; 29: 713-21.
- Dengler V., Galbraith M., Espinosa J. Transcriptional regulation by hypoxia inducible factors // Crit. Rev. Biochem. Mol. Biol. - 2014; 49: 1-15.
- Livak K., Schmittgen T. Analysis of Relative gene expression data using realtime Quantitative PCR and the 2(-Delta DeltaC(T)) // Method. Methods. - 2001; 25 (4): 402-28.
- D'Amico A., Whittington R., Malkowicz S. et al. Combined modality staging of prostate carcinoma and its utility in predicting pathologic stage and postoperative prostate specific antigen failure // Urology. - 1997; 49 (3A Suppl): 23-30.
- Kietzmann T., Mennerich D., Dimova E. Hypoxia-inducible factors (HIFs) and phosphorylation: impact on stability, localization, and transactivity // Front. Cell Dev. Biol. - 2016; 4: 11.
- Dery M., Michaud M., Richard D. Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators // Int. J. Biochem. Cell. Biol. - 2005; 37: 535-40.
- Benitez D., Hermoso M., Pozo-Guisado E. et al. Regulation of cell survival by resveratrol involves inhibition of NF-kB - regulation gene expression in prostate cancer cells // Prostate. - 2009; 69: 1045-54.
补充文件
