Vol 30, No 2 (2019)

The paper presents Russia’s first case of successful use of a 8-week therapy course using an original interferon-free combination of the third-generation NS3/4A protease inhibitor glecaprevir (GLE) and the second-generation NS5A-replication enzyme inhibitor pibrentasvir (PIB) in clinical practice to treat HCV infection genotype 3A with mixed cryoglobulinemia syndrome and concomitant HBV infection in a patient with chronic kidney disease C5d, who received chronic dialysis after elective bilateral nephrectomy for renal polycystosis and awaited donor kidney transplantation.

There is no specific pathogenetic therapy for dust lung diseases (pneumoconiosis); approaches to symptomatic bronchodilator therapy are described. The issues of prevention and sociomedical examination in these diseases are discussed.

One of the common causes of worse quality of life and disability in the active population of almost all ages is dry eye syndrome (DES), a set of corneal and conjunctival changes caused by systematic tear film destabilization. In some cases DES causes severe changes in the cornea - its irreversible opacities, ulcerations, and even perforation. DES treatment and prevention with drugs that moisturize the ocular surface is the therapy of choice. There are a significant amount of tear substitutes on the market, but when making a choice, it is important to remember about the need for long-term treatment of the ocular surface and the safety of the components of an eye medication.

The author shows that in localized prostate cancer, one of the mechanisms of activation of the transcriptional potential of cancer cells and early recurrence of the disease is to increase the expression of the HIFIa and NF-kB genes in glandular tissue.

The concurrence of chronic obstructive pulmonary disease and tuberculosis significantly increases the likelihood of cardiac structural and functional changes, by raising the risk of cardio-vascular disease, which aggravates the course of both the underlying and concomitant diseases.

Oligosecretory monoclonal gammopathy is the result of the hyperproduction of a small proliferating cell clone, which, after various periods, can transform into overt secreting hematological tumors, but may be a cause of non-tumor organ and tissue damage, including kidney disease. The frequency, severity, and spectrum of monoclonal gammopathy in patients from different departments of a multidisciplinary therapeutic hospital have been studied. The nosological characteristics of diseases associated with monoclonal gamma of undetermined significance (MGUS) are given; special attention is paid to kidney diseases, including immune-mediated diseases, the association of which to MGUS has been least studied.

The paper considers the issues of pharmacokinetics and pharmacodynamics of famciclovir in the treatment of herpesvirus infections. Investigations have demonstrated the high efficacy of famciclovir, especially in the treatment of manifestations of herpesvirus infections, accompanied by neurological symptoms, such as pain. It also describes the efficacy of short-cycle famciclovir, which increases patient adherence to treatment and allows the latter to be initiated as soon as possible at the first symptoms of recurrence.

Today, recombinant prourokinase is an indispensable Russian enzyme preparation in ophthalmology. Gemase, the active ingredient of which is a human recombinant prourokinase, is capable of quickly eliminating massive hemorrhages into the vitreous body, retina and anterior chamber of the eye. The drug is widely used in hemorrhagic forms of diabetic retinopathy, hypertensive retinopathy, and age-related macular degeneration with a hemorrhagic component. It is effective in treating eye injuries, postoperative fibrinoid syndromes, thrombosis of the central retinal vein and its branches, occlusions of the central retinal artery and its branches.