USE OF PEPSAN-R IN THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE

O Minushkin; Минушкин О; I Loranskaya; Лоранская И; I Zverkov; Зверков И; L Rakitskaya; Ракитская Л; L Mamedova; Мамедова Л; V Vishnevskaya; Вишневская В; L Maslovskiy; Масловский Л; O Minushkin; Minushkin O; I Loranskaya; Loranskaya I; I Zverkov; Zverkov I; L Rakitskaya; Rakitskaya L; L Mamedova; Mamedova L; I Vishnevskaya; Vishnevskaya I; L Maslovsky; Maslovsky L

USE OF PEPSAN-R IN THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE

Authors: Minushkin O¹, Loranskaya I¹, Zverkov I¹, Rakitskaya L¹, Mamedova L¹, Vishnevskaya V¹, Maslovskiy L¹, Minushkin O², Loranskaya I³, Zverkov I², Rakitskaya L³, Mamedova L³, Vishnevskaya I³, Maslovsky L²
Affiliations:
2. Medical Center, RF President's Administration of Affairs
3. Russian Medical Academy of Postgraduate Education
Issue: Vol 20, No 3 (2009)
Pages: 43-46
Section: Articles
URL: https://journals.eco-vector.com/0236-3054/article/view/115335
ID: 115335

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Abstract

The anti-inflammatory effect of Pepsan-R that is new to the Russian Federation, used as monotherapy in 50 patients with 0-first degree gastroesophageal reflux disease (GERD), was evaluated. The drug contains 2 active ingredients: guaiazulene and dimeticone. The mechanism of its action is to suppress mast cell degranulation and to generate a protective layer on the gastroesophageal mucosa. The efficacy of the agent was clinically shown in 100% of the patients (10% of them needed larger doses of the drug). Four-week positive changes were morphoendoscopically seen in 50% of the patients. No side effects were recorded

Keywords

gastroesophageal reflux disease, treatment, Pepsan-R

References

Akagi M., Matsui N., Mochizuki S. et al. Inhibitory effect of egualen sodium: a new stable derivate of azulen on histamine release from mast cell-like cells in the stomach // Pharmacology. - 2001; 63 (4): 203-209.
Barclay R.L., Dinda P.K., Morris G.P et al. Morphologycal evidence of mast cell degranulation in an animal model of acid-induced esophageal mucosal injuri // Dig Dis Sci. -1995; 40 (8): 1651-1658.
Kourounakis A.P., Rekka E.A., Kourounakis P.N. Antioxidant activity of guaiazulene and protection against paracetamol hepatoxicity in rats //J. Pharm. Pharmacol. - 1997; 49 (9): 938-942.
Oh T.Y., Lee J.S., Ahn B.O. et al. Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxodants in its treatment // Free Radic Biol Med. - 2001; 30 (8): 905-915.

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USE OF PEPSAN-R IN THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE

Full Text

Abstract

Keywords

About the authors

References

Supplementary files

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