COMBINATION THERAPY IS A SIGNIFICANT STEP FORWARD FOR TREATING ARTERIAL HYPERTENSION


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Abstract

Russian National Research Medical University, Moscow The efficiency of using the fixed combination perindopril and amlodipine (Prestance, Servier, France) wasconsideredin patients with arterial hypertension (AH). Fifteen patients (mean age 55.13±11.1 years) with Stage II AH, grades ll-lll, andamoderate-to-high-risk for cardiovascular events, including those concurrent with coronary heart disease, were examined. Biochemical blood tests, Korotkoff office blood pressure (BP) measurements, and 24-hour BP monitoring were performed before and during treatment. Prestance was given once daily; the follow-up was 4 weeks. The use of Prestance resulted in a significant reduction in systolic and diastolic BP (SBP and DBP), a morning rise of SBP, and the rate of morning increase in DBP and unchanged both daytime and nocturnal heart rate. In addition, metabolic neutrality and no side effects of the fixed combination perindopril and amlodipine (Prestance, Servier, France) wereshown.

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