USE OF PEPSAN-R IN THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The paper analyzes the results of treatment with Pepsan-R that has anti-inflammatory activity by virtue of the fact that the inflammatory mediator is histamine and Pepsan-R blocks its containing mast cells in 50 patients with gastroesophageal reflux disease (GERD). Two formulations of the drug (gel and capsules) were evaluated. The average treatment duration was 28 days. Pepsan-R compares well with the currently accepted treatment options in the time of exacerbation abolishment, which causes the authors to recommend it for the treatment of GERD, by using mono- or combination therapy in relation to the form and severity of the disease.

Full Text

Restricted Access

About the authors

O. Minushkin

Training and Research Medical Center, Department for Presidential Affairs of the Russian Federation

Email: redvrach@rusvrach.ru

I. Zverkov

Training and Research Medical Center, Department for Presidential Affairs of the Russian Federation

Email: redvrach@rusvrach.ru

I. Loranskaya

Training and Research Medical Center, Department for Presidential Affairs of the Russian Federation

Email: redvrach@rusvrach.ru

Yu. Tugova

Training and Research Medical Center, Department for Presidential Affairs of the Russian Federation

Email: redvrach@rusvrach.ru

References

  1. Диагностика и лечение гастроэзофагеальной рефлюксной болезни: пособие для врачей / под ред. В.Т. Ивашкина, М., 2005, - 30 с.
  2. Григорьев П.Я., Яковенко Э. П. Клиническая гастроэнтерология. - М.: МИА., 2001. - 693 с.
  3. Григорьев П.Я., Яковенко Э. П. Краткое формулярное руководство по гастроэнтерологии и гепатологии. - М., 2003, - 112 с.
  4. Ивашкин В.Т., Трухманов А.С. Болезни пищевода, - М.: Триада. 2000. - 179 с.
  5. Клинические рекомендации - гастроэнтерология / под ред. В.Т. Ивашкина. - М.: ГЭТАР-Медиа. 2006. - 208 с.
  6. Минушкин О.Н., Масловский Л.В., Теплухина О.Ю. и др. Гастроэзофагеальная рефлюксная болезнь: эпидемиологические, патогенетические, клинико-диагностические и терапевтические аспекты // Consillium medicum - 2006; 2: 31-37.
  7. Akagi М., Matsui N., Mochizuki S. et al. Inhibitory effect of egualen sodium: a new stable derivate of azulen on histamine release from mast cell - like cells in the stomach // Pharmacology. - 2001: 63 (4): 203-209.
  8. Barclay R. L., Dinda P. K., Morris G. P. et al. Morphologycal evidence of mast cell degranulation in an animal model of acid-induced esophageal mucosal injuri // Dig Dis Sсi. - 1995; 40 (8): 1651-1658.
  9. Kourounakis A.P., Rekka E.A., Kourounakis P. N. Antioxidant activity of guaiazulene and protection against paracetamol hepatoxicity in rats // J. Pharm. Pharmacol. -1997; 49 (9): 938-942.
  10. Kourounakis A.P., Rekka E.A., Kourounakis P.N. Effect of guaiazulene on some cytochrome P. 450 activities. Implication in metabolic activation and hepatoxicity paracetamol // Arch. Pharm. - 1997; 330 (1-2): 7-11.
  11. Lee J.S., Oh T. Y., Ahn B.O. et al. Involvement of oxidate stress in experimentally induced reflux esophagitis and Barretts esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants // Mytat. Res. - 2001; 1 (480-481): 189-200.
  12. h T.Y., Lee J. S., Ahn В. O. et al. Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxodants in its treatment // Free Radic. Biol. Med. - 2001; 30(8); 905-915.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2012 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies