EFFECT OF ANTIALLERGIC INTRANASAL MEDICATIONS ON THE VIBRATION RATE FOR CILIATED EPITHELIAL CILIA IN VITRO


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Abstract

In vitro experiments have provided evidence that intranasal antiallergic medications containing disodium cromoglycate, dimethindene maleate, and azelastine hydrochloride affect the vibration rate of nasal cilia, which should be taken into account in clinical practice.

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About the authors

J. Alberty

Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde Münster, Germany

Email: redvrach@rusvrach.ru

W. Stoll

Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde Münster, Germany

Email: redvrach@rusvrach.ru

References

  1. Deitmer T. Physiology and pathology of the mucociliary system // Adv Otorhinolaryngol. - 1989; 43: 1-143.
  2. Sakakura Y., Mucociliary function during experimentally induced rhinovirus infection in man // Ann. Otol. Rhinol. Laryngol. - 1974; 82: 203-211.
  3. Sakakura Y., Ukai K., Majima Y. et al. Nasal mucociliary clearance under various conditions // Acta Otolaryngol. (Stockh). - 1983; 96: 167-173.
  4. Ohashi Y., Nakai Y., Kihara S. et al. Ciliary activity in patients with nasal allergies // Eur. Arch. Otorhinolaryngol. - 1985; 242: 141-147.
  5. Deitmer T., Scheffler R. The effect of different preparations of nasal decongestants on ciliary beat frequency in vitro // Rhinology. - 1993; 31: 151-153.
  6. van de Donk H., van den Heuvel A., Zuidema J. et al. The effects of nasal drops and their additives on human nasal mucociliary clearance // Rhinology. -1982; 20: 127-137.
  7. Albegger K. Symptomatische Therapie der allergischen Rhinitis // Laryngol. Rhinol. Otol. (Stuttg). - 1990; 69: 613-620.
  8. Lund V., Seasonal allergic rhinitis - a review of current therapy // Allergy. -1996; 51: 5-7.
  9. Meltzer E., Storms W., Pierson W. et al. Efficacy of azelastine in perennial allergic rhinitis; clinical and rhinomanometric evaluation // J. Allergy Clin. Immunol. -1988; 82: 447-455.
  10. Gatspar H., Nolte D., Aurich R. et al. Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis // Allergy. - 1994; 49: 152-158.
  11. Charpin D., Godard P., Garay R. et al. A multicenter clinical study of the efficacy and tolerability of azelastine nasal spray in the treatment of seasonal allergic rhinitis: a comparison with oral cetrizine. // Eur. Arch. Otorhinolaryngol. -1995; 252: 455-458.
  12. Dalhamn T., Rylander R. Frequency of ciliary beat measured with a photosensitive cell // Nature. - 1962; 196: 592-593.
  13. Riechelmann H., Hafner B., Mann W. Ziliare Aktivitat und Sekrettransport bei der allergischen Reaktion der N'asenschleimhaut // Allergologie. - 1992: 15: 224-228.
  14. Su X., Po A. The effect of some commercially available antihistamine and decongestant intranasal formulations on ciliary beat frequency // J. Clin. Pharm. Ther. - 1993; 18: 219-222.
  15. Tamaoki J., Chiyotani A., Sakai N. et al. Effect of azelastine on sulphur dioxide induced impairment of ciliary motility in airway epithelium // Thorax. - 1993; 48: 542-546.
  16. Merkus F., Schusler van Hees M. Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance // Allergy. - 1992; 47: 230-233.
  17. van de Donk H., Zuidema J., Merkus F. The influence of the pH and osmotic pressure upon tracheal ciliary beat frequency as determined with a new photoelectric registration device // Rhinology. - 1980; 18: 93-104.
  18. Ingels K., Kortmann M., Nijziel M. et al. Factors influencing ciliary beat measurements // Rhinology. - 1991; 29: 7-26.
  19. Breuninger H. Uber das physikalisch-chemische Verhaltcn des Nasenschleims // Arch. Klin. Exp. Ohren. Nasen Kehlkopfheilk. - 1964; 184: 133-138.
  20. van de Donk H., Muller-Plantema I., Zuidema J. et al. The effects of preservatives on the ciliary beat frequency of chicken embryo tracheas. // Rhinology. -1980; 18: 119-133.
  21. van de Donk H., Zuidema J., Merkus F. The effects of nasal drops on the ciliary beat frequency of chicken embryo tracheas. // Rhinology. - 1981; 19: 215-230.
  22. Horak F., Jager S., Nirnbergcr G. et al. Pharmacodynamic dose finding of dimethindene in a sustained release formulation // Arzneimittelforschung. - 1993; 43: 1193-1195.
  23. Horak F., Jager S., Berger U. et al. Controlled exposure to mite allergen for a dose finding of dimethindene maleate (DMM) // Agents Actions. - 1994; 41: 124-126.
  24. Ciprandi G., Pronzato C., Passalacqua G. et al. Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity // J. Allergy. Clin. Immunol. - 1996; 98: 1088-1096.
  25. Shirasaki H., Asakura K., Sohma S. et al. Inhibitory effects of azelastine on nasal allergic responses in sensitized guinea pigs // Eur. Arch. Otorhinolaryngol. -1992; 249: 279-282.

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