SPECIFIC FEATURES OF THERAPY FOR ERECTILE DYSFNCTI0N IN PATIENTS WITH HYPOGONADISM
- Authors: Rozhivanov R1, Kurbatov D1, Rozhivanov F.2, Kurbatov D2
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Affiliations:
- Endocrinology Research Center, Russian Agency for Medical Technologies
- Issue: Vol 20, No 3 (2009)
- Pages: 65-69
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115366
- ID: 115366
Cite item
Abstract
Since erectile dysfunction is frequently accompanied by hypogonadism, this study has been undertaken to define indications for combined therapy with phosphodiesterase type V inhibitors in combination with androgens. Androgen monotherapy have turned out to be effective in 67.6% of patients. It is advisable to use combined therapy to patients with severe and moderate erectile dysfunction, diabetes mellitus and/or coronary heart disease shortly after these conditions are diagnosed. However, there is an earlier occurrence of benefits from therapy with phosphodiesterase type V inhibitors if androgens have been previously used.
Keywords
About the authors
R Rozhivanov
D Kurbatov
Ft Rozhivanov
Endocrinology Research Center, Russian Agency for Medical Technologies; Endocrinology Research Center, Russian Agency for Medical Technologies
D Kurbatov
Endocrinology Research Center, Russian Agency for Medical Technologies; Endocrinology Research Center, Russian Agency for Medical Technologies
References
- Курбатов Д. Г., Кузнецкий Ю. Я., Петричко М. И. Лечение эректильной дисфункции у больных с гипогонадизмом // Андрология и генитальная хирургия.-2006; 4:41-47.
- Мериних Д., МакДермотт М. Секреты эндокринологии. - М, 1998. - С. 308.
- Нарушения половой функции у мужчин при сахарном диабете. Под ред. Коган М.И.-М., 2005. -224 с.
- Рафальский В.В. Подходы к рациональному выбору ингибиторов фосфодиэстеразы 5 типа//Фарматека. - 2004; 19(20): 1-8.
- Aversa A., Isidori A., De Martino M. et al. Androgens and penile erection: evidence for direct relationship between free testosterone and cavernous vasodilatation in men with erectile dysfunction // Clin Endocrinol. - 2000; 53:517-522.
- Brock G. Oral agents: First-line therapy for erectile dysfunction // Eur. Urol. -2002;1:12-18.
- Carani C., Granata A., Bancroft J. et al. The effects of testosterone replacement on nocturnal penile tumescence and rigidity and erectile response to visual erotic stimuli in hypogonadal men // Psychoneuroendocrinology. -1995; 20 (7): 743-753.
- Carani C., Granata A., Faustini F. et al. Prolactin and testosterone: their role in male sexual function // Int. J. Androl. -1996; 19:48-54.
- Feldman H., Golstein I., Hatzichristou D. et al. Importence and its medical and psychological correlates: results of the Massachusetts Male Aging Study // J. Urol. (Baltimore).-1994; 151:54-61.
- Finley M., Curruthers M. Androgens, the prostate and safety of testosterone treatment // The Aging Male. - 2006; 9 (1): 4.
- Holmquist F., Persson K., Bodker A. et al. Some pre- and postjunctional effects of castration in rabbit isolated corpus cavernosum and urethra // J. Urol. (Baltimore). -1994; 152:1011-1016.
- ISA, ISSAM, EAU, E AA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males. - The Aging Male. - 2008.
- Kurbatov D. Verbesserte Differenzialdiagnose vaskulogener Erektionsstorungen mit Hilfe der Magnitresonanztomographie // Androgen.info. - Nov. 2006. - P. 106-108.
- Laumann E., Paik A., Rosen R. Sexual dysfunction in Unuted States: prevalence and predictors //JAMA. -1999; 281:537-544.
- National Institutes of health consensus development panel on impotence // JAMA.-1993; 270: 83-90.
- Palese M., Crone J., Burnett A. A castrated mouse model of erectile dysfunction // J. Androl. - 2003; 24:699-703.
- Park K., Ku J., Kim S. et al. Risk factors in predicting a poor response to sildenafil citrate in elderly men with erectile dysfunction // BJU Int. - 2005; 95 (3): 366-370.
- Rochira V., Balestrieri A., Madeo B. et al. Sildenafil Improves Sleep-Related Erections in Hypogonadal Men: Evidence From a Randomized, Placebo-Controlled, Crossover Study of a Synergic Role for Both Testosterone and Sildenafil on Penile Erections // J. Androl. - 2006; 27:165-175.
- Shabsigh R. The effects of testosterone on the cavernous tissue and erectile function // World J. Urol. -1997; 15 (1): 21-26.
- Vernet D., Cai L, Garbin H. et al. Reduction of penile nitrogen oxide synthase in diabetic BB/WOR (type 1) and BBZ/WOZ (type II) rats with erectile dysfunction // Endocrinology. -1995; 136:5709-5717.
- Vinik A., Richardson D. Erectile dysfunction in diabetes // Diabetes Rev. -1998; 6(1): 16-33.
- Yassin A., Diede H.-E., Saad F. et al. Combination therapy of Tadalafil&Testosterone in hypogonadal non-responders // Int. J. Impot. Res. - 2003; 15 (6): 27.
- Yassin A., Saad F. Long-Acting Testosterone Ester injection as a First Line Therapy in hypogonadal patients with Erectile Dysfunction // Int. J. Androl. - 2005; 28 (1):53.