NEPHROGENIC ANEMIA: AN INDIVIDUAL APPROACH TO ITS TREATMENT


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The treatment of nephrogenic anemia may be unsafe, clearly manifesting itself when large-dose erythropoietic stimulants are used. In this case it is particularly important to estimate the expected benefits and risks of the therapy in a specific patient and the possibilities of reducing the dose of stimulants.

Full Text

Restricted Access

About the authors

V. Ryasnyansky

I.I. Mechnikov Northwestern State Medical Academy

Email: ryasn2006@rambler.ru
Associate Professor, Candidate of Medical Sciences Saint Petersburg

G. Shostka

I.I. Mechnikov Northwestern State Medical Academy

Professor, MD Saint Petersburg

References

  1. Varat M., Adolph R., Fowler N. Cardiovascular effects of anemia // Am. Heart. J. - 1972; 83 (3): 415-26.
  2. Hertig A., Ferrer-Marin F. Correction of anaemia on dialysis: did we forget physiology? // Nephrol. Dial. Transplant. - 2011; 26 (4): 1120-2.
  3. McFarlane P., Pisoni R., Eichleay M., Wald R., Port F. Mendelssohn D International trends in erythropoietin use and hemoglobin levels in hemodialysis patients // Kidney Int. - 2010; 78: 215-23.
  4. Besarab A., Bolton W., Browne J. et al. The effects of normal as compared with low hematocrit values in patients with Med. - 1998; 339: 584-90.
  5. Drueke T., Locatelli F., Clyne N. et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia // N. Engl. J. Med. - 2006; 355: 2071-84.
  6. Singh A., Sczcech L., Tang K. et al. Correction of anemia with epoetin alfa in chronic kidney disease // N. Engl. J. Med. - 2006; 355: 2085-98.
  7. Pfeffer M., Burdmann E., Chen C. et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease // N. Engl. J. Med. - 2009; 362: 2019-32.
  8. Kainz A., Mayer B., Kramar R., Oberbauer R. Association of ESA hyporesponsiveness and haemoglobin variability with mortality in haemodialysis patients // Nephrol. Dial. Transplant. - 2010; 25: 3701-6.
  9. Bonafont X., Bock A., Carter D et al. A meta-analysis of the relative doses of erythropoiesis-stimulating agents in patients undergoing dialysis // NDT Plus. -2009; 2 (5): 347-53.
  10. Bock A., Hirt-Minkowski P, Brünisholz M. et al. Swiss EFIXNES trial investigators Darbepoetin alpha in lower-than-equimolar doses maintains haemoglobin levels in stable haemodialysis patients converting from epoetin alpha/ beta // Nephrol. Dial. Transplant. - 2008; 23: 301-8.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2012 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies