ALCOHOLIC HEPATITIS: CLINICAL AND MORPHOLOGICAL FEATURES, DIAGNOSIS, TREATMENT
- Authors: Podymova S.1
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University
- Issue: Vol 23, No 12 (2012)
- Pages: 2-9
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115530
- ID: 115530
Cite item
Open Access
Access granted
Abstract
The paper provides the clinical and morphological characteristics of acute and chronic alcoholic hepatitis. It analyzes different clinical types of acute alcoholic hepatitis (AAH): icteric (usually a severe type), fulminant, cholestatic, and latent. The possibilities of AAH treatment are considered. Severe AAH serves as an indication for the use of glucocorticosteroids or pentoxifylline; it is sufficient to withdraw from alcohol and to use metabolic agents in moderate alcoholic hepatitis. The paper gives data on the universal action of essentiale on the pathogenetic components of liver damage.
Full Text
About the authors
S. Podymova
I.M. Sechenov First Moscow State Medical University
Email: redvrach@rusvrach.ru
Professor MD, Honored Scientist of the Russian Federation
References
- Ивашкин В.Т. Алкогольная болезнь печени. Современные аспекты мембранной терапии печени. Материалы симпозиума «Эссенциальные фосфолипиды в лечении поражений печени» / М., 1997; 10-2.
- Хронический вирусный гепатит. Под ред. В.В. Серова, З.Г. Апросиной / М.: Медицина, 2002; с. 80-96.
- Хазанов А.И. Современные проблемы вирусных и алкогольных болезней печени // Рос. журн. гастроэнтерол., гепатол., колопроктол. - 2002; 12 (2): 6-13.
- Arai M., Gordon E., Lieber C. Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa, content and changes in phospholipids // Biochim. Biophys. Acta. - 1984; 797: 320-7.
- Diseases of the Liver and Biliary Tract. Standardization of Nomenclature, Diagnostic Criteria, and Prognosis (Editorial Committee C. Leevy, S. Sherlock, N. Tygstrup et al.) // Raver Press New York. - 1994; 205 p.
- Lieber C. Alkoholic liver diseas: in sigths in pathogenesis lead to new treatment // Hepatology. - 2000; 32 (Suppl. 1): 113-28.
- Mathurin P. et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. // J. Hepatol. - 2002; 36 (4): 480-7.
- Waturu Okiyama, Naoki Tanaka, Tamie Nakajima et al. Polienephophatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress // J. Hepatol. - 2009; 50: 1236-46.
- Wiley T., Carthy M., Breidi L. et al. Impact of alcohol on the histological and clinical progression of hepatiyis C infection // Hepatology. - 1998; 28: 805-9.
Supplementary files
