THE BLOOD LEVELS OF OMENTIN AND OTHER ADIPOKINES IN PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE
- Authors: Verbovoy A.1, Solomonova E.1
-
Affiliations:
- Samara State Medical University
- Issue: Vol 23, No 11 (2012)
- Pages: 79-81
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115621
- ID: 115621
Cite item
Open Access
Access granted
Abstract
One hundred and one patients with a mean age of 62,1±1,2 years and impaired glucose tolerance (IGT) were examined. A control group consisted of 16 apparently healthy individuals with a mean age of 22,6±0,6 years. The values of glycemia and lipid spectrum and the blood levels of insulin, C-reactive protein, adiponectin, resistin, endothelin, and omentin were determined. The patients with IGTin the presence of visceral obesity were observed to have atherogenic dyslipidemia, hyperinsulinemia, aseptic adipose tissue inflammation, and lower blood omentin levels. In women with IGT, blood resistin and endothelin concentrations were elevated; adiponectin levels tended to fall.
Keywords
Full Text
About the authors
A. Verbovoy
Samara State Medical UniversityProfessor MD
E. Solomonova
Samara State Medical University
Email: solomonova.el@yandex.ru
Candidate of Medical Sciences
References
- Гозмаков О.А. Система эндотелиновых пептидов: механизмы эндоваскулярных патологий // Кардиология. - 2000; 1: 32-9.
- Клебанова Е.М., Балаболкин М.И., Креминская В.М. Значение жировой ткани и ее гормонов в механизмах инсулиновой резистентности и развитии сахарного диабета 2 типа // Клин. мед. - 2007; 7: 20-7.
- Шварц В., Бад Колберг. Жировая ткань как эндокринный орган // Проблемы эндокринол. - 2009; 1 (55): 38-44.
- Шварц В., Бад Колберг. Воспаление жировой ткани // Проблемы эндокринол. - 2009; 4 (55): 44-8.
- Berg A., Combs T., Du X. et al. The adipocite-secreted protein Acrp30 enhances hepatic insulin action. // Nat. Med. - 2001; 7: 947-52.
- Banerjee R., Rangwala S., Shapiro J. et al. Regulation of fasted blood glucose by resistin // Science. - 2004; 5661 (303): 1195-8.
- Combs T., Berg A., Obici S. et al. Endogenous glicose production is inhibited by the adipose - derived protein acrp 30 // J. Clin. Invest. - 2001; 198: 1875-81.
- De Souza Batista C., Yang R., Lee M. et al. Omentin plasma levels and gene expression are decreased in obesity // Diabetes. - 2007; 56: 1655-61.
- Moore G., Chapman H., Holder J. et al. Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice // Biochem. Biophys. Res. Commun. - 2001; 286: 735-41.
- Moreno-Navarrete et al. Circulating omentin concentration increase after weight loss // Nutrion & Metabolism. - 2010; 7: 27.
- Rajala M., Obici S., Scherer P. et al. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production // J. Clin. Invest. - 2003; 111: 225-30.
- Steppan C., Balley S., Bhat S. et al. // Nature. - 2001; 409: 307-12.
Supplementary files
