DOPAMINERGIC THERAPY IN PATIENTS WITH CHRONIC CEREBROVASCULAR INSUFFICIENCY
- Authors: Bogolepova A.1, Chukanova E.1
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Affiliations:
- N.I. Pirogov Russian National Research Medical University
- Issue: Vol 24, No 3 (2013)
- Pages: 25-27
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115653
- ID: 115653
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Abstract
Chronic brain ischemia (CBI) is considered as individual cerebrovascular syndrome that manifests itself as a complex of neuropsychological and neurological symptoms. Trials have provided support for the efficacy and safety of Pronoran (piribedil), a nonergolinic dopamine receptor agonist, its effects on cognitive, psychoemotional, and motor disorders in patients with CBI. At 60 days of treatment, the drug exerted a significant leveling effect on static and gait disturbances. According to the Mini-Mental State Examination (MMSE) scale and Montreal Cognitive Assessment (MoCA) test, 68% of the patients had ameliorated cognitive and affective disorders as compared with the baseline. There was no significant improvement in Hospital Anxiety and Depression Scale scores, which was likely to be associated with the fact that a relatively small group of patients had been examined and they had only subclinical symptoms of anxiety and depression when they had been included into the study; however, there was regression of anxiety and depressive disorders and emotional normalization in 79% of the patients.
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About the authors
A. Bogolepova
N.I. Pirogov Russian National Research Medical University
Email: AnnaBogolepova@yandex.ru
E. Chukanova
N.I. Pirogov Russian National Research Medical University
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