SIGNIFICANCE OF N34S MUTATION IN THE SPINK1 GENE IN CHANGING THE CLINICAL COURSE OF CHRONIC PANCREATITIS
- Authors: Kucheryavyi Y.1, Tibilova Z.1, Andreev D.1, Smirnov A.2
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Affiliations:
- A. I. Evdokimov Moscow State University of Medicine and Dentistry
- Polyclinic Two, Ministry of Economic Development of Russia
- Issue: Vol 24, No 10 (2013)
- Pages: 28-32
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115774
- ID: 115774
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Abstract
The investigation showed that the N34S mutation in the SPINK1 gene (a pancreatic secretory trypsin inhibitor gene) was most common in patients with toxic and idiopathic chronic pancreatitis (CP). The significantly high rate of identification of the above mutation in patients with complicated forms of idiopathic CP suggests the increased risk of disease complications.
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About the authors
Yu. Kucheryavyi
A. I. Evdokimov Moscow State University of Medicine and DentistryCandidate of Medical Sciences
Z. Tibilova
A. I. Evdokimov Moscow State University of Medicine and Dentistry
D. Andreev
A. I. Evdokimov Moscow State University of Medicine and Dentistry
A. Smirnov
Polyclinic Two, Ministry of Economic Development of Russia
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