HEPATOCYTE DYSPLASIA IN HBeAg-NEGATIVE CHRONIC HEPATITIS B WITH DIFFERENT HBsAg PHENOTYPES OF VIRAL INFECTION
- Authors: Dudanova O.1, Pravdolyubova I.1
-
Affiliations:
- Petrozavodsk State University
- Issue: Vol 24, No 10 (2013)
- Pages: 63-66
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115822
- ID: 115822
Cite item
Abstract
Examination of 58 patients with HBeAg-negative chronic hepatitis B (CHB) with HBsAg +- and HBsAg - phenotypes of hepatitis B virus infection revealed a considerable predominance of small liver cell dysplasia over large liver cell one, an upward trend for liver cell dysplasia in HBsAg loss, and a direct correlation of hepatocyte dysplasia with the magnitude of a necrotic/inflammatory process and the hepatocyte levels of HBcorAg in HBsAg -.
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About the authors
O. Dudanova
Petrozavodsk State University
Email: odudanova@gmail.com
MD
I. Pravdolyubova
Petrozavodsk State UniversityCandidate of Medical Sciences
References
- Дуданова О.П., Киселев О.И. Хронический гепатит В: диагностика и особенности клинического течения / Петрозаводск: ПетрГУ, 2013; 112 с.
- Правдолюбова И.А. Клинико-морфологические особенности хронического HBeAg-негативного гепатита В и хронического гепатита С. Автореф. дис.. канд. мед. наук. Петрозаводск: ПетрГУ, 2013; 22 с.
- Ярошенко Е.Б., Бурневич Э.З., Мойсюк Я.Г. Роль вирусных гепатитов в развитии гепатоцеллюлярной карциномы // Практ. онкол. - 2008; 9 (4): 189-93.
- Anthony P., Vogel C., Barker L. Liver cell dysplasia: a premalignant condition // J. Clin. Pathol. - 1973; 26: 217-23.
- Chisari F., Isogawa M., Wieland S. Pathogenesis of Hepatitis B Virus Infection // Pathol. Biol. - 2010; 58 (4): 258-66.
- El-Serag H. Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma // Gastroenterology. - 2012; 142 (6): 1264-73.
- Henmi A., Uchida T., Shikata T. Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma: Evidence against precancerous nature of liver cell dysplasia // Cancer. - 1985; 55: 2594-9.
- Hsieh Y., Su I., Wang H. et al. Hepatitis B Virus Pre-S2 Mutant Surface Antigen Induces Degradation of Cyclin-Dependent Kinase Inhibitor p27Kip1through c-Jun Activation Domain-Binding Protein I // Mol. Cancer Res. - 2007; 5 (10): 1063-72.
- Kao J., Liu C., Jow G. et al. Fine mapping of hepatitis B virus pre-S deletion and its association with hepatocellular carcinoma // Liver Int. - 2012; 32 (9): 1373-81.
- Kew M. Hepatitis B virus Х protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma // J. Gastroenterol. Hepatol. - 2011; 1: 144-52.
- Lee R., Tsamandas A., Demetris A. Large cell change (liver cell dysplasia) and hepatocel-lular carcinoma in cirrhosis: Matched case-control study, pathological analysis, and pathogenetic hypothesis // Hepatology. - 1997; 26: 1415-22.
- Sinn D., Choi M., Gwak G. et al. Pre-s mutation is a significant risk factor for hepatocellular carcinoma development: a long-term retrospective cohort study // Dig. Dis. Sci. - 2013; 58 (3): 751-8.
- Watanabe S., Okita K., Harada T. et al. Morphologic studies of the liver cell dysplasia // Cancer. - 1983; 51: 2197-205.
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