PROBLEMS IN THE DIAGNOSIS OF SUBCLINICAL HYPERCORTICISM IN ADRENAL INCIDENTALOMAS


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Abstract

Subclinical hypercorticism (SH) is characterized by impaired cortisol secretion without specific clinical manifestations of hypercorticism. According to various sources, the prevalence of SH varies between 5-30% among patients with adrenal masses. Sixty-four patients with adrenal incidentalomas were examined; 11 of them were found to have SH. Surgery was performed in 1 patient. Based on the findings, the authors propose an algorithm for examination of patients with adrenal incidentalomas for SH.

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About the authors

A. Dreval

M.F. Vladimirsky Moscow Regional Clinical Research Institute

I. Komerdus

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Candidate of Medical Sciences

A. Murzina

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Email: anastasiya-murzina@mail.ru

R. Tishenina

M.F. Vladimirsky Moscow Regional Clinical Research Institute

G. Stashuk

M.F. Vladimirsky Moscow Regional Clinical Research Institute

L. Denisova

M.F. Vladimirsky Moscow Regional Clinical Research Institute

A. Platonova

M.F. Vladimirsky Moscow Regional Clinical Research Institute

References

  1. Бельцевич Д.Г., Кузнецов Н.С., Ванушко В.Э. Инциденталома надпочечников // Эндокрин. хир. - 2009; 1 (4): 19-23.
  2. Дедов И.И., Мельниченко Г.А., Трошина Е.А. и др. Болезнь Иценко-Кушинга (патогенез, клиника, диагностика, лечение). Методическое пособие для врачей. М., 2000; 40 с.
  3. Arlt W., Allolio B. Adrenal insufficiency // Lancet. - 2003; 361 (9372): 1881-93.
  4. Aron D. The adrenal incidentaloma: disease of modern technology and public health problem // Rev. Endocr. Metab. Disord. - 2001; 2 (3): 335-42.
  5. Barzon L., Sonino N., Fallo F. et al. Prevalence and natural history of adrenal incidentalomas // Eur. J. Endocr. - 2003; 149 (4): 273-85.
  6. Barzon L., Scaroni C., Sonino N. et al. Risk factors and long-term follow-up of adrenal incidentalomas // J. Clin. Endocrinol. Metab. - 1999; 84 (2): 520-6.
  7. Grumbach M., Biller B., Braunstein G. et al. Management of the clinically inapparent adrenal mass («incidentaloma») // Ann. Int. Med. - 2003; 138 (5): 424-9.
  8. Kloos R., Gross M., Francis I. et al. Incidentally discovered adrenal masses // Endocr. Rev. - 1995; 16 (6): 460-84.
  9. Nieman L., Biller В., Findling J. et al. The Diagnosis of Cushing’s Syndrome: An Endocrine Society Clinical Practice Guideline // J. Clin. Endocrinol. Metab. -2008; 93 (5): 1526-40.
  10. Mansmann G., Lau J., Balk E. et al. The clinically inapparent adrenal mass: update in diagnosis and management // Endocr. Rev. - 2004; 25 (2): 309-40.
  11. Osella G., Terzolo M., Borretta G. et al. Endocrine evaluation of incidentally discovered adrenal masses (incidentalomas) // J. Clin. Endocrinol. Metab. - 1994; 79 (6): 1532-9.
  12. Reincke M. Subclinical Cushing’s syndrome // Endocrinol. Metab. Clin. North Am. - 2000; 29 (1): 43-56.
  13. Rossi R., Tauchmanova L., Luciano A. et al. Subclinical Cushing’s syndrome in patients with adrenal incidentaloma: clinical and biochemical features // J. Clin. Endocrinol. Metab. - 2000; 85 (4): 1440-8.
  14. Terzolo M., Bovio S., Reimondo G. et al. Subclinical Cushing’s syndrome in adrenal incidentalomas // Endocrinol. Metab. Clin. North Am. - 2005; 34 (2): 423-39.
  15. Tsagarakis S., Vassiliadi D., Thalassinos N. Endogenous subclinical hypercortisolism: diagnostic uncertainties and clinical implications // J. Endocrinol. Invest. - 2006; 29 (5): 471-82.

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