USE OF ACETYLCYSTEINE IN CLINICAL PULMONOLOGY
- Authors: Novikova L.1, Baranova O.1, Ilkovich Y.1
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Affiliations:
- Acad. I.P. Pavlov Saint Petersburg State Medical University
- Issue: Vol 25, No 2 (2014)
- Pages: 13-16
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115879
- ID: 115879
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Abstract
The paper considers the new possibilities of using acetylcysteine known as a mucolytic agent in clinical pulmonology. Particular emphasis is placed on its antioxidant and antitoxic effects. The authors have proven the efficacy of acetylcysteine used in some interstitial and rare lung diseases.
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About the authors
L. Novikova
Acad. I.P. Pavlov Saint Petersburg State Medical University
Email: novikoval06@mail.ru
Candidate of Medical Sciences
O. Baranova
Acad. I.P. Pavlov Saint Petersburg State Medical UniversityCandidate of Medical Sciences
Yu. Ilkovich
Acad. I.P. Pavlov Saint Petersburg State Medical UniversityCandidate of Medical Sciences
References
- Гембицкая Т.Е., Новикова Л.Н., Черменский А.Г. и др. Ацетилцистеин при острых и хронических болезнях органов дыхания // Врач. - 2011; 3: 48-52.
- Кахновский И.М., Гостищева О.В. Оценка влияния ацетилцистеина на реологические свойства мокроты // Клин. фармакология и терапия. - 1997; 6: 29-30.
- Рациональная фармакотерапия заболеваний органов дыхания: Рук.для практикующих врачей. Под общ. ред. А.Г. Чучалина / М.: Литтера, 2004; 874 с.
- Aruoma O., Halliwell B., Hoey B. et al. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid // Free Radic. Biol. Med. - 1989; 6 (6): 593-77.
- Braga P., Ziment I., Allegra L. Classification of agents that act on bronchial mucus; in: Braga P., Allegra L. (eds): Drugs in Bronchial Mucology / New York: Raven Press, 1989; 59-67.
- Duijvestijn Y. et al. Acetilcisteina y carbocisteina para las infecciones agudas de las vias aereas superiores e inferiores en pacientes pediatricos sin enfermedad broncopulmonar cronica (Revision Cochrane traducida) / En: Biblioteca Cochrane Plus. 2009.
- Global Strategy for the diagnisis, management and prevention of Chronic Obstructive Lung Disease (GOLD) Updated 2014. www.goldcopd.org
- Piperno E., Berssenbruegge D. Reversal of experimental paracetamol toxicosis with N-acetylcysteine // Lancet. - 1976; 2 (7988): 738-9.
- Reichenberger F., Tamm M. N-acetylcystein in the therapy of chronic bronchitis // Pneumologie. - 2002; 56 (12): 793-7.
- Shen Y., Cai W., Lei S. et al. Effect of High/Low Dose N-Acetylcysteine on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis // COPD. - 2013 Dec 30. Epub. ahead of print
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