HEPATIC FUNCTIONAL IMPAIRMENT IN THE FIRST HALF OF PREGNANCY
- Authors: Uspenskaya Y.1, Kuznetsova I.1, Goncharenko N.1, Sukhanova G.2
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Affiliations:
- I.M. Sechenov First Moscow Medical University
- Hematology Research Center
- Issue: Vol 24, No 12 (2013)
- Pages: 70-73
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115935
- ID: 115935
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Open Access
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Abstract
The paper discusses the possible mechanisms of liver damage as a consequence of the failing compensatory capacities of metabolic enzymatic systems in pregnant women exposed to high concentrations of endo- and exogenous sex hormones. It proposes measures to prevent this condition. Ursodeoxycholic acid preparations are shown to be highly effective and safe in normalizing laboratory markers for liver damage in the first half of pregnancy.
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About the authors
Yu. Uspenskaya
I.M. Sechenov First Moscow Medical University
Email: jusp@mail.ru
Candidate of Medical Sciences
I. Kuznetsova
I.M. Sechenov First Moscow Medical University
N. Goncharenko
I.M. Sechenov First Moscow Medical University
G. Sukhanova
Hematology Research CenterMoscow
References
- Andrade S., Gurwitz J., Davis R. et al. Prescription drug use in pregnancy // Am. J. Obstet. Gynecol. - 2004; 191: 398-407.
- Chen C., Wu M., Chen H. et al. Relationships of serum pro-inflammatory cytokines and vascular endothelial growth factor with liver dysfunction in severe ovarian hyperstimulation syndrome // Hum. Reprod. - 2000; 15 (1): 66-71.
- Fabregues F., Balasch J., Ginès P. et al. Ascites and liver test abnormalities during severe ovarian hyperstimulation syndrome // Am. J. Gastroenterol. - 1999; 94 (4): 994-9.
- Glover D., Amonkar M., Rybeck B. et al. Prescription, over-the-counter,and herbal medicine use in a rural, obstetric population // Am. J. Obstet. Gynecol. -2003; 188: 1039-45.
- Isoherranen N., Thummel K. Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes? // Drug. Metab. Dispos. - 2013; 41 (2): 256-62.
- Kopylov U., Avidan B., Papageorgiou N. et al. Idiopathic liver function test abnormality in pregnancy is associated with assisted reproduction techniques // Fertil. Steril. - 2013; 99 (2): 377-81.
- Mei-Dan E., Wiznitzer A., Sergienko R. et al. Prediction of preeclampsia: liver function tests during the first 20 gestational weeks // J. Matern. Fetal. Neonatal. Med. - 2013; 26 (3): 250-3.
- Obrzut B., Kuczyński W., Grygoruk C. et al. Liver dysfunction in severe ovarian hyperstimulation syndrome // Gynecol. Endocrinol. - 2005; 21 (1): 45-9.
- Papageorgiou I., Grepper S., Unadkat J. Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines // Drug. Metab. Dispos. - 2013; 41 (2): 281-90.
- Rizk B. Ovarian Hyperstimulation Syndrome - Epidemiology, Pathophysiology, Prevention and Management, 1st edn. / New York: Cambridge University Press, 2006; 10-33.
- Ryley N., Forman R., Barlow D. et al. Liver abnormality in ovarian hyperstimulation syndrome // Hum. Reprod. - 1990; 5 (8): 938-43.
- Simpson K., Lukacs N., Colletti L. et al. Cytokines and the liver // J. Hepatol. - 1997; 27 (6): 1120-32.
- Sueldo C.E. Transient liver function tests abnormalities in OHSS// Fertil. Steril. - 1988; 50 (6): 995-6.
- Toyoda Y., Endo S., Tsuneyama K. et al. Mechanism of exacerbative effect of progesterone on drug-induced liver injury // Toxicol. Sci. - 2012; 126 (1): 16-27.
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