Vol 24, No 12 (2013)

Asthmatic patients without the 16ArgArg+ genotype were recorded to develop exacerbations more frequently if they do not receive adequate anti-inflammatory therapy. The use of inhaled glucocorticosteroids, as well as long-acting β-adrenomimetics for planned therapy in the patients can substantially reduce the number of exacerbations.

In parallel with the prevalence of obesity, the number of its complications, including breathing problems, is on the increase. The paper discusses recognized obesity concomitants, such as obstructive sleep apnea syndrome and obesity hypoventilation syndrome.

The results of studies on the use of nonsteroidal anti-inflammatory drugs for the purpose of comparing the effectiveness of the treatment of patients with diseases of the pharynx.

The premenopausal women with arterial hypertension (AH) and dyslipidemia in hypoestrogenemia were found to have significant structural and functional alterations in the vessel wall as atherosclerosis. Better results were obtained in the group receiving combination therapy with Mertenil (rosuvastatin) and Diroton (lisinopril).

We present the analysis of experimental and clinical researches of the drug Preductal administration. We have showed the effectiveness of this medicine for preventive measures for cardiovascular complications with patients with different forms of ischemic heart disease.

Twenty-two manganese proteins and 9 cuproenzymes are involved in human iron metabolism. Iron monotherapy fails to take into account trace element interactions and may be therefore accompanied by the higher rates of side effects, and, in case of copper deficiency, may cause the body’s iron overload or treatment refractoriness. The use of a combination of iron, copper, and manganese allows such results to be avoided.

There is evidence that the hydrophilic angiotensin-converting enzyme inhibitor lisinopril may be used as a first-line drug to treat elderly hypertensive patients with significant comorbidity, including this drug as part of multicomponent therapy.

The given observation demonstrates how carefully collected history data, clinical picture assessment, and an understanding of the bounds and possibilities of examination techniques can establish a correct diagnosis.

The presence of two gallbladders that develop equally or differently and that are located in many different ways is a rare anomaly of the biliary system. The paper describes a case of complete gallbladder duplication in a female woman with cholelithiasis.

The paper gives the results of studying the association of apolipoprotein E gene polymorphism in a Moscow population with the development of primary ischemic stroke.

Using the results of analyzing the literature and some his findings, the author considers one of the aspects of the pathogenesis of neuroleptic cardiomyopathy that is a little studied iatrogenic disease caused by the adverse cardiotoxic effect of antipsychotic drugs. The cardiotoxic effects of neuroleptics include myocardial ischemia that underlies myocardial dysfunction and ventricular remodeling. The mechanism for the development of myocardial ischemia at an organ level is associated with hypotension and persistent tachycardia, which are constant concomitants of neuroleptic therapy.