SYSTEMIC INFLAMMATORY RESPONSE SYNDROME AND A POSSIBLE WAY OF ITS CORRECTION IN ACUTE PANCREATITIS


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Abstract

High mortality rates from acute pancreatitis (AP) remain one of the relevant problems of current urgent surgery. A fetal outcome in the first disease period arises from the development of systemic inflammatory response syndrome and multiorgan dysfunction due to the release of the inflammatory mediators cytokines in peripheral circulation. The possibilities of pharmacological correction of complications in the first period of AP have been studied.

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About the authors

V. GORSKY

N.I. Pirogov Russian National Research Medical University

Email: getinfo911@mail.ru
Professor

M. AGAPOV

N.I. Pirogov Russian National Research Medical University

Candidate of Medical Sciences

M. KHOREVA

N.I. Pirogov Russian National Research Medical University

Candidate of Medical Sciences

References

  1. Ковальчук Л.В., Хорева М.В., Варивода А.С. и др. Роль рецепторов врожденного иммунитета в развитии острого инфаркта миокарда // Журн. микробиол. - 2008; 4: 64-8.
  2. Ковальчук Л.В., Хорева М.В., Варивода А.С. и др. Рецепторы врожденного иммунитета: подходы к количественной и функциональной оценке Toll-подобных рецепторов // Иммунология. - 2008; 4: 223-7.
  3. Abraham E., Laterre P., Garbino J. et al. Lenercept Study Group. Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebocontrolled, multicenter phase III trial with 1,342 patients // Crit. Care Med. - 2001; 29: 503-10.
  4. Bhatia M., Brady M., Shokuhi S. et al. Inflammatory mediators in acute pancreatitis // J. Pathol. - 2000; 90: 117-25.
  5. Bianchi M. DAMPs, PAMPs and alarmins: all we need to know about danger // J. Leukoc. Biol. - 2007; 81: 1-5.
  6. Bone R., Balk R., Cerra F. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. ACCP/SCCM Consensus Conference Committee, American College of Chest Physicians/Society of Critical Care Medicine // Chest. - 1992; 101: 1644-55.
  7. Hietaranta A., Mustonen H., Puolakkainen P. et al. Proinflammatory effects of pancreatic elastase are mediated trough TLR4 and NF-kB // Biochem. Biophys. Res. Commun. - 2004; 323 (1): 192-6.
  8. Hong-Guang Li, Zong-Guang Zhou, Yuan Li. Alterations of Toll-like Receptor 4 Expression on Peripheral Blood Monocytes During the Early Stage of Human Acute Pancreatitis // Dig. Dis. Sci. Published online: 6 April 2007
  9. Medzhitov R. Toll-like receptors and innate immunity // Nat. Rev. Immunol. - 2001; 1: 135-45.
  10. Moore F., Moore E. Evolving concepts in the pathogenesis of post injury multiple organ failure // Surg. Clin. North Am. - 1995; 75: 257-77.
  11. Sabroe I., Parker L., Dower S. et al. The role of TLR activation in inflammation // J. Pathol. - 2008; 214 (2): 126-35.
  12. Takeda K., Kaisho T., Akira S. Toll-like receptors // Annu. Rev. Immunol. -2003; 21: 335-76.
  13. Tsan Min-Fu, Gao B. Endogenous ligands of Toll-like receptors // J. Leuk. Biol. - 2004; 76: 514-9.
  14. Ulloa L., Tracey K. The «cytokine profile»: a code for sepsis // Trends Mol. Med. - 2005; 11: 56-63.
  15. Weber C., Adler G. From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis // Pancreatology. - 2001; 1: 356-62.

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