LOCAL NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN THE TREATMENT OF TONSILLOPHARYNGITIS


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Abstract

Sore throat caused by tonsillopharyngitis in the vast majority of cases is a very frequent reason people visit their doctor. Symptomatic therapy aimed mainly at relieving pain plays a large role in the treatment of tonsillopharyngitis. The local nonsteroidal ant-inflammatory drug flurbiprofen has the high efficacy and safety established in evidence-based clinical trials.

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About the authors

A. Kiselev

Novosibirsk State Medical University

Professor

I. Dronov

I.M. Sechenov First Moscow State Medical University

Email: dronow@yandex.ru
Candidate of Medical Sciences

References

  1. Linder J., Bates D., Lee G. et al. Antibiotic treatment of children with sore throat // JAMA. - 2005; 294 (18): 2315-22.
  2. Linder J., Stafford R. Antibiotic treatment of adults with sore throat by community primary care physicians: a national survey, 1989-1999 // JAMA. -2001; 286 (10): 1181-6.
  3. Worrall G. Acute sore throat // Can. Fam. Physician. - 2007; 53 (11): 1961-2.
  4. Pifleiro-Pérez R., Hijano-Bandera F., Alvez-Gonzalez F. et al. Consensus document on the diagnosis and treatment of acute tonsillopharyngitis // An. Pediatr. Barc. - 2011; 75 (5): 1-13.
  5. Принципы этиопатогенетической терапия острых фарингитов: Методические рекомендации. Составитель: С.В. Рязанцев / СПб, 2013; 32 с.
  6. Козлов С.Н., Страчунский Л.С., Рачина С.А. Фармакотерапия острого тонзиллофарингита в амбулаторной практике: результаты многоцентрового фармакоэпидемиологического исследования // Тер. арх. - 2004; 76 (5): 45-51.
  7. Portier H., Grappin M., Chavanet P. New strategies for angina case management in France // Bull. Acad. Natl. Med. - 2003; 187 (6): 1107-16.
  8. Андреева И.В. Фармакоэпидемиология антибактериальных препаратов у населения. Автореф. дис.. канд. мед. наук. Смоленск, 2003; 21 с.
  9. Шпынев К.В., Кречиков В.А. Современные подходы к диагностике стрептококкового фарингита // Клин. микробиол. антимикроб. химиотер. -2007; 9 (1): 20-33.
  10. Отвагин И.В., Соколов Н.С. Современные аспекты диагностики инфекций, вызванных стрептококками группы А // Клин. микробиол. антимикроб. химиотер. - 2011; 13 (3): 223-30.
  11. Maltezou H., Tsagris V., Antoniadou A. et al. Evaluation of a rapid antigen detection test in the diagnosis of streptococcal pharyngitis in children and its impact on antibiotic prescription //J. Antimicrob. Chemother. - 2008; 62 (6): 1407-12.
  12. Ayanruoh S., Waseem M., Quee F. et al. Impact of rapid streptococcal test on antibiotic use in a pediatric emergency department // Pediatr. Emerg. Care. -2009; 25 (11): 748-50.
  13. Dronov I., Botneva A., Neskorodova K. et al. The experience of rapid diagnosis of streptococcal tonsillopharyngitis in children in outpatient care. 24th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain, 10-13 May 2014, poster R342.
  14. Клиническая фармакология по Гудману и Гилману / М.: Практика, 2006; 1648 с.
  15. Abdel-Aziz A., Al-Badr A., Hafez G. Flurbiprofen // Profiles Drug Subst. Excip. Relat. Methodol. - 2012; 37: 113-81.
  16. Chalmers I., Cathcart B., Kumar E. et al. Clinico-pharmacological studies and clinical evaluation of flurbiprofen. A new non-steroidal antirheumatic agent // Ann. Rheum. Dis. - 1972; 31 (4): 319-24.
  17. URL: http://www.ncbi.nlm.nih.gov/pubmed (обращение 12.01.2015).
  18. Kim S., Chang Y., Cho H. et al. Non-steroidal anti-inflammatory drugs for the common cold // Cochrane Database Syst. Rev. - 2013; 6: CD006362.
  19. Schachtel B., Aspley S., Shephard A. et al. Utility of the sore throat pain model in a multiple-dose assessment of the acute analgesic flurbiprofen: a randomized controlled study // Trials. - 2014; 3 (15): 263.
  20. Schachtel B., Homan H., Gibb I. et al. Demonstration of dose response of flurbiprofen lozenges with the sore throat pain model // Clin. Pharmacol. Ther. -2002; 71 (5): 375-80.
  21. Watson N., Nimmo W., Christian J. et al. Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomised, double-blind, placebo-controlled study of efficacy and safety // Int. J. Clin. Pract. - 2000; 54 (8): 490-6.
  22. Benrimoj S., Langford J., Christian J. et al. Efficacy and tolerability of the anti-inflammatory throat lozenge flurbiprofen 8.75mg in the treatment of sore throat // Clin. Drug Investigation. - 2001; 21 (3): 183-93.
  23. Сединкин А.А., Баландин А.В., Димова А.Д. Результаты открытого проспективного контролируемого рандомизированного сравнительного исследования эффективности и переносимости таблеток для рассасывания флурбипрофен (стрепфен) и парацетамола у больных с болью в горле при острых инфекционно-воспалительных заболеваниях верхних дыхательных путей // Вестник оториноларингол. - 2004; 5: 52-4.
  24. Russo M., Bloch M., de Looze F. et al. Flurbiprofen microgranules for relief of sore throat: a randomised, double-blind trial // Br. J. Gen. Pract. - 2013; 63: 149-55.
  25. Blagden M., Christian J., Miller K. et al. Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, double-blind, placebo-controlled study in UK general practice centres // Int. J. Clin. Pract. - 2002; 56 (2): 95-100.
  26. Schachtel B., Aspley S., Shephard A. et al. Onset of action of a lozenge containing flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled trial with a new method for measuring onset of analgesic activity // Pain - 2014; 155 (2): 422-8.
  27. Shephard A., Smith G., Aspley S. et al. Randomised, double-blind, placebo-controlled studies on flurbiprofen 8.75 mg lozenges in patients with/without group A or C streptococcal throat infection, with an assessment of clinicians' prediction of «strep throat» // Int. J. Clin. Pract. - 2014; Epub. Ahead of print.

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