PATHOGENETICALLY TARGETED THERAPY FOR GASTROESOPHAGEAL REFLUX DISEASE
- Authors: Starostln B.1
-
Affiliations:
- City Clinical Polyclinic Thirty-Eight
- Issue: Vol 26, No 1 (2015)
- Pages: 36-39
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/116164
- ID: 116164
Cite item
Abstract
The paper provides evidence that pathogenetically targeted therapy with a combination of a proton pump inhibitor and an alginate (Gaviscon® Double Action) should be used in gastroesophageal reflux disease.
Full Text
About the authors
B. Starostln
City Clinical Polyclinic Thirty-Eight
Email: borstar56@yandex.ru
Saint Petersburg
References
- Старостин Б.Д. Гастроэзофагеальная рефлюксная болезнь (часть I). Эпидемиология, факторы риска // Гастроэнтерология Санкт-Петербурга. -2014; 1-2: 2-14.
- Kahrilas P. Gastroesophageal reflux disease // JAMA. - 1996; 276: 983-8.
- Старостин Б.Д. Гастроэзофагеальная рефлюксная болезнь // Рус. мед. журн. - 1997; 5 (2): 72-80.
- Исаков В.А., Морозов С.В., Ставраки Е.С. и др. Анализ распространенности изжоги: национальное эпидемиологическое исследование взрослого городского населения (АРИАДНА) // Экспер. и клин. гастроэнтерол. - 2008; 1: 20-9.
- Лазебник Л.Б., Машарова А.А., Бордин Д.С. и др. Результаты многоцентрового исследования «Эпидемиология гастроэзофагеальной рефлюксной болезни в России» (МЭГРЕ) // Тер. арх. - 2011; 16: 45-50.
- Старостин Б.Д. Гастроэзофагеальная рефлюксная болезнь (часть II). Этиопатогенез, клиника, диагностика // Гастроэнтерология Санкт-Петербурга. - 2014; 3-4: 2-14.
- Tytgat G., McColl K., Tack J. et al. New algorithm for the treatment of gastro-oesophageal reflux disease // Aliment. Pharmacol. Ther. - 2008; 27: 249-56.
- Fletcher J. et al. Unbuffered Highly Acidic Gastric Juice Exists at the Gastroesophageal Junction After a Meal // Gastroenterology. - 2001; 121: 77583.
- Beamont H., Bennink R., de Jong J. et al. The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD // Gut. - 2010; 59 (4): 441-51.
- Namasiovayam V., Katzka D. Extraesophageal reflux Definition and Pathophysiology. In: AJ DiMarino Jr, S. Cohen, ed. Extraesophageal Manifestations of GERD. Slack Incorporated, 2013; 1-19.
- Clarke A., Wirz A., Manning J. et al. Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket // Gut. - 2008; 57: 292-7.
- Pandolfino J. et al. Acidity Surrounding the Squamocolumnar Junction in GERD Patients: «Acid Pocket» Versus «Acid Film» // Am. J. Gastroenterol. - 2007; 102: 263-4.
- Kahrilas P. et al. The Acid Pocket: A Target for Treatment in Reflux Disease? // Am. J. Gastroenterol. - 2013; 108: 1058-64.
- Beaumont H., Boeckxstaens G. Scintigraphic imaging of the acid pocket: an enlarged pocket with acid coating the distal esophagus in GERD patients with hiatal hernia. 2009.
- Kahrilas P., Boeckxstaens G., Smout A. Management of the patient with incomplete response to PPI therapy // Best Practice & Res. Clin. Gastroenterol. -2013; 27: 401-14.
- Manabe N., Haruma K., Ito M. et al. Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trial // Dis. Esophagus. - 2012; 25: 373-80.
- Chiu C.-T. et al. Randomised clinical trial: sodium alginate oral suspension is non-inferior to omeprazole in the treatment of patients with non-erosive gastroesophageal disease // Aliment. Pharmacol. Ther. - 2013; 38 (9): 1054-64.
- Wang Y.-K. et al. Current Pharmacological Management of Gastroesophageal Reflux Disease // Gastroenterol Res. Pract. - 2013; http://dx.doi.org/10.1155/2013/983653
- Boeckxstaens G. et al. Symptomatic reflux disease: the present, the past and the future // Gut. - 2014; 63: 1185-93.