THE PARAMETERS OF HEMOSTASIS PROTEIN AND LIPID METABOLISM IN RELATION TO THE DURATION OF TYPE 2 DIABETES MELLITUS


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Abstract

The parameters of hemostasis protein and lipid spectrum were comprehensively analyzed in 196 patients with type 2 diabetes mellitus (DM2) in relation to its duration. It was ascertained that the platelet coagulation hemostatic changes occurring at the onset of DM2 were unrelated to the duration of the disease and associated with alterations in carbohydrate, protein, and lipid metabolic parameters, the pattern of which was determined by the duration of DM2.

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About the authors

G. Petrik

Kuban State Medical University

Email: pgg@mail.ru

S. Pavllshchuk

Kuban State Medical University

References

  1. ACCORD Study Group. Effect of Combination Lipid Therapy in Type 2 Diabetes Melitus // N. Engl. J. Med. - 2010; 362: 1563-74.
  2. Michelson A. Platelets. Second Edition / Academic Press, 2007; p. 697-713.
  3. Алгоритмы специализированной медицинской помощи больным сахарным диабетом (4-е изд.). Под. ред. И.И. Дедова, М.В. Шестаковой / М., 2009; 103 с.
  4. Петрик Г.Г., Павлищук С.А. Показатели метаболизма и гемостаза у больных с сахарным диабетом 2-го типа с различной выраженностью ангиопатий // Пробл. эндокринол. - 2010; 2: 15-9.
  5. Sparks J., Sparks C. Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes // J. Biol. Chem. - 1990; 265: 8854-62.
  6. Reven G. Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profil. The price paid to maintain glucose homeostasis in insulin-resistant individuals // Endocrinol. Metab. Clin. North Am. - 2005; 34: 49-62.
  7. Lukens F. The influence of insulin on protein metabolism // Diabetes. - 1953; 2: 491-5.
  8. Шевченко О.П., Долгов В.В., Олиференко Г.А. Электрофорез в клинической лаборатории / М.: Реафарм, 2006; 160 с.
  9. Taylor K. Diabetes and the heart. 1-st. Ed. / Oxford: Oxford, 1992.
  10. Боднар П.И. Роль нарушений белкового обмена в патогенезе диабетических ангиопатий // Пробл. эндокринол. - 1973; 2: 3-7.
  11. Le Dévéhat C., Khodabandehlou T., Vimeux M. Diabetes mellitus and fibrinogen. Hemorrheological and microcirculatory consequences // J. Mal. Vasc. - 2000; 25 (1): 53-7.
  12. Corrado E., Rizzo M., Muratori I. Assotiation of elevated fibrinogen and CRP levels with carotid lesions in patiets with newly diagnosed hypertensionor type 2 diabetes //Arch. Med. Res. - 2006; 3798: 1004-9.
  13. Kannel W., D'Agostino R., Wilson P. et al. Diabetes, fibrinogen, and risk of cardiovascular disease: the Framingham experience // Am. Heart J. - 1990; 120: 672-6.
  14. Ferretti G., Rabini R., Bacchetti T. et al. Glycated Low Density Lipoproteins Modify Platelet Properties: A Compositional and Functional Study // J. Clin. Endocrinol & Metabolism. - 2002; 87 (5): 2180-4.
  15. Caimi G., Presti R., Montana M. Membrane fluidity, membrane lipid pattern, and cytosolic Ca2+ content in platelets from a group of type II diabetic patients with macrovascular complications // Diabetes Care. - 1995; 18 (1): 60-3.
  16. Watala C., Boncer M., Golanski J. et al. Platelet membrane lipid fluidity and intraplatelet calcium mobilization in type 2 diabetes mellitus // Eur. J. Haematol. -1998; 61: 319-26.
  17. Tschoepe B. Pathobiology and cell interactions of platelets in diabetes // Diab. Vasc. Dis. Res. - 2005; 2: 16-23.
  18. Vaidyula V., Boden G., Rao K. Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects // Platelets. - 2006; 17 (8): 498-500.
  19. Balletshofer B., Rittig K., Enderle M. et al. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance // Circulation. - 2000; 101: 1780-4.
  20. Singleton J., Smith A., Russell J. et al. Microvascular Complications of Impaired Glucose Tolerance diabetes // Diabetes. - 2003; 52: 2867.

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