Vol 26, No 6 (2015)

The article presents literature data on the problem of aging, a marked increase in the number of elderly and senile age in the world; examines various theories of aging. It was found that the most relevant theory of aging, at the moment, is the theory of oxidative stress (free radical theory). It is revealed that with age there is an increase in the number of active forms of oxygen in the cells, the intensity of oxidative processes in the mitochondria and decreased antioxidant protection. Currently actively being sought methods of influence on oxidative stress, we conducted a study of natural and synthetic antioxidants, evaluates their impact on the intensity of oxidative processes in cells and the human body in General. Underway to develop new antioxidants, a three-dimensional supramolecular compounds that have intrinsic antioxidant activity.

Data of the review of literature on a problem of urological pathology at advanced and senile age are presented in article.

Pathology of the musculoskeletal system is widespread in the population and, together with involutive changes are among the most frequent diseases of elderly patients. The most significant of them - osteoporosis, osteoarthritis, and sarcopenia. All three components in isolation, of course, lead to reduced quality of life. In this paper, the problem of interference of these states and their joint impact on the musculoskeletal system as a target organ; examined ways to improve the diagnostic search of osteoporosis, osteoarthritis, and sarcopenia. It was noted that in addition to performing standard diagnostic algorithm of these states, the important is to use specialized (geriatric) diagnostics. It emphasizes that, given the integration of the pathology of the musculoskeletal system for the effectiveness of medical and medico-social rehabilitation programs require the use and development is integrated techniques.

Current technologies of preventive geriatrics and antiaging medicine are aimed at elaborating and implementing effective individual programs to prevent the development and progression of chronic diseases and age-related conditions.

The paper considers the etiology, pathogenesis, and clinical features of insomnias at an elderly age, as well as prevention measures and general principles in the correction of sleep disorders in elderly patients

The paper gives data on organ-sparing operations for breast cancer (BC) and describes contraindications to them. These operations are radical and a rehabilitation method for female patients.

To optimize prospective methods of evaluation of drugs interchangeability a patent research was conducted. The results of the patent research are presented in this article. The outcome of this exploration will help to optimize the process of comparative evaluation of the reference drug and generic (or biosimilar).

The investigators have studied the efficacy of an Osteomed group in the combination treatment of postmenopausal osteoporosis, by applying a personified approach.

One of the most valid methods of diagnosing gastroesophageal reflux disease is the determination of the presence of gastroesophageal reflux from the data of daily pH-metry. Statistically significant differences have been established in the key pH-metry values depending on age. Correlation analysis has revealed the major factors that influence these values.

The efficiency of using [-2]proPSA and its derivative a p2PSA to free prostate-specific antigen (PSA) ratio (%p2PSA) for the early detection of prostate cancer in men with a total prostate-specific antigen level of 2 to 10 ng/ml.

Pulse wave velocity, pulse pressure, body mass index, and systolic blood pressure were found to affect the rate of biological ageing particularly in hypertensive patients.

The time course of changes in C-protein levels in relation to the site of an infection/inflammation focus was studied in patients with facial erysipelas and lower extremity erysipelas (including this condition in the presence of chronic venous insufficiency).

The article performs modern analysis of preventive geriatrics methods implementation economic efficiency, reflecting improvement of life expectancy and quality, which can be achieved by using this method. The main result of anti-aging medicine is prolongation of active life, satisfaction of patients by their appearance and general amelioration of life quality, growth of the number of employees and their productivity.