THE XENOBIOTIC DETOXIFICATION SYSTEM IN THE THERAPY OF THREATENED ABORTION
- Authors: Makarov O.1, Lunina S.1, Salnikova L.2, Lutsenko N.1, Goncharova V.1
-
Affiliations:
- N.I. Pirogov Russian National Research Medical University
- N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences
- Issue: Vol 27, No 4 (2016)
- Pages: 49-53
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/116544
- ID: 116544
Cite item
Open Access
Access granted
Abstract
Despite performed therapy for abortion, the highest risk of miscarriage was associated with a combination of the risky alleles of the ABCB1 and GSTP1 genes; the frequency of this combination was 13.2%.
Full Text
About the authors
O. Makarov
N.I. Pirogov Russian National Research Medical UniversityProfessor
S. Lunina
N.I. Pirogov Russian National Research Medical University
Email: Svetlana.lunina2011@yandex.ru
L. Salnikova
N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences
N. Lutsenko
N.I. Pirogov Russian National Research Medical University
V. Goncharova
N.I. Pirogov Russian National Research Medical University
References
- Сальникова Л.Е., Замулаева И.А., Белопольская О.Б. и др. Встречаемость TCR-мутантных лимфоцитов у человека в зависимости от генотипов по локусам детоксикации ксенобиотиков // Экологическая генетика. - 2010; 8 (2): 18-23.
- Бочков Н.П. Клиническая генетика / М.: ГЭОТАР-Мед, 2002; 457 с.
- Bansal T., Jaggi M., Khar R. et al. Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy // J. Pharm. Pharmaceut. Sci. -2009; 12 (1): 46-78.
- Diergaarde B., Potter J., Jupe E. et al. Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer // Cancer Epidemiol. Biomarkers Prev. - 2008; 17 (7): 1751-9.
- Fertuck K., Matthews J., Zacharewski T. Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo // Toxicol. Sci. - 2001; 59 (2): 231-40.
- Hall M., Handley M., Gottesman M. Is resistance useless? Multidrug resistance and collateral sensitivity // Trends Pharmacol. Sci. - 2009; 30 (10): 546-56.
- Hamajima N. PCR-CTPP: a new genotyping technique in the era of genetic epidemiology // Exp. Rev. Mol. Diagn. - 2001; 1 (1): 119-23.
- Harbottle A., Daly A., Atherton K. et al. Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance-associated protein 1 in acquired doxorubicin resistance // Intern. J. Cancer. - 2001; 92 (6): 777-83.
- Josephy P. Genetic Variations in Human Glutathione Transferase Enzymes: Significance for Pharmacology and Toxicology // Human Genom. Prot. Vol. - 2010 (2010), Article ID 876940, 14 pages doi: 10.4061/2010/876940 URL: http://www. sage-hindawi.com/journals/hgp/2010/876940/
- Lamba J., Strom S., Venkataramanan R. et al. MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype // Clin. Pharmacol. Ther. - 2006; 79 (4): 325-38.
- Pasanen M. The expression and regulation of drug metabolism in human placenta // Adv. Drug Deliv. Rev. - 1999; 38: 81-97.
- Schilling C., Gallicchio L., Miller S. et al. Genetic polymorphisms, hormone levels, and hot flashes in midlife women // Maturitas. - 2007; 57 (2): 120-31.
- Shimada T., Watanabe J., Sutter T. et al. Catalytic properties of polymorphic human cytochrome P450 1B1 variants // Carcinogenesis. - 1999; 20 (8): 1607-13.
- Van Lieshout E., Knapen M., Lange W. Localization of glutathione S-transferases alpha and pi in human embryonic tissues at 8 weeks gestational age // Human Reprod. - 1998; 13 (5): 1380-6.
- Guengerich F. Cytochrome P 450s, drugs and diseases // Mol. Interv. -2003; 3 (4): 8-18.
Supplementary files
