Vol 27, No 4 (2016)

The paper provides the results of studying the specific features of the clinical picture and outcomes of erythema nodosum in pregnant women.

Vertebrogenic pains are a heterogeneous group of abnormalities, which encompasses musculoskeletal dysfunction and nerve root compression. Oral nonsteroidal anti-inflammatory drugs (NSAIDs) are indicated to ease pain syndrome and local inflammation. NSAIDs have also proven to be effective when topically applied.

The paper considers the diagnostic possibilities of noninvasive life-time method for the early diagnosis and differential diagnosis of pigmented and nonpigmented skin tumors.

The paper gives data on potential benefits to a patient and a surgeon from introducing probiotics into clinical practice to treat surgical diseases. Numerous studies have demonstrated a lower risk for surgical site infections, anastomotic incompetence, and pulmonary and urologic complications when the probiotics are used. An attempt has been made to summarize available information about this and to give specific recommendations for the choice of a probiotic, its dosage, and the frequency and duration of its use in surgical patients.

The paper presents the results of a questionnaire survey among multidisciplinary hospital surgeons regarding the antibiotic prevention of surgical site infections. It gives data on errors frequently encountered in the antibiotic prevention,

Electrographic changes caused by the side cardiotoxic effect of antipsychotics assist in the early detection of evolving cardiac dysfunction.

The impact of therapy with an angiotensin-converting enzyme inhibitor (Lisinopril) in combination with a third-generation calcium channel blocker (amlodipine) on blood pressure level, left cardiac remodeling, and silent myocardial ischemia in 133 antihypertensive women with estrogen deficiency in the late fertile period in relation to the genotype of the estrogen receptor gene.

Obesity is an urgent problem of modern medicine not only because of a steep rise in its incidence. Most obese people suffer from depression and/or have other psychological problems. Understanding the mechanisms of bidirectional risks between obesity and common mental disorders is necessary for the effective treatment and prevention of these diseases.

Chronic brain ischemia (CBI) is manifested by a set of neuropsychological and neurological symptoms. Cognitive impairments detected in patients with CBI largely determine their state. Just at the earliest stages of CBI, there is abnormal metabolism of mediators, primarily dopaminergic, cholinergic, and glutamatergic ones. One of the drugs that modulate the dopaminergic system is Piribedil (Pronoran) that belongs to nonergolinic dopamine receptor agonists and stimulates D2 and D3 receptors. Numerous trials confirm its safety and efficacy in affecting cognitive, psychoemotional, and motor disorders in patients with CBI.

The efficacy of melatonin, a hormone made by the pineal gland, in treating climacteric syndrome in postmenopausal women has been investigated.

The paper gives the results of a comparative evaluation of using nootropics, such as piracetam and choline alfoscerate (gliatilin). Gliatilin has been ascertained to exert a more pronounced positive effect than nootropil in correcting cognitive functions and astheno-autonomic disorders.

The integral indices of the result of therapy were calculated on the basis of a questionnaire survey (the treatment efficiency (rationality) and a benefit-cost criterion) allow the most clinically effective strategy for a specific patient.