ПАТОГЕНЕТИЧЕСКИЕ МЕХАНИЗМЫ, ЛЕЖАЩИЕ В ОСНОВЕ РАЗВИТИЯ ОСТЕОАРТРОЗА, И СПОСОБЫ ИХ КОРРЕКЦИИ
- Авторы: Марьяновский А.1
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Учреждения:
- РНИМУ им. Н.И. Пирогова
- Выпуск: Том 27, № 7 (2016)
- Страницы: 48-51
- Раздел: Статьи
- URL: https://journals.eco-vector.com/0236-3054/article/view/116674
- ID: 116674
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Аннотация
Дегенеративно-дистрофические заболевания суставов и позвоночника занимают 1-е место по распространенности среди болезней опорнодвигательной системы. Рассмотрены подходы к патогенетической терапии остеоартроза с применением хорошо изученных препаратов, безопасность которых при длительном применении доказана.
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Об авторах
А. Марьяновский
РНИМУ им. Н.И. Пирогова
Email: docaam@yandex.ru
доктор медицинских наук, профессор Москва
Список литературы
- Lozada C., del Rio E., Reitberg D. et al. A multi-center double-blind, randomized, controlled trial (db-RCT) to evaluate the effectiveness and safety of co-administered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections versus IA placebo in patients with moderate-to-severe pain associated with OA of the knee // Arthritis Rheumatol. - 2014; 66 (suppl.): S1266.
- Lesiak A., Gottwald R., Weiser M. Skutecznosc kuracji preparatem Zeel T w iniekcjach dostawowych okolostawowych i domiesniowych w chorobie zwyrodnieniowej stawow // Medycyna Biologiczna. - 2001; 2: 30-6.
- Gottwald R., Weiser M. Treatment of osteoarthritis of the knee with Zeel T // Medicina Biolögica. - 2000; 13 (4): 109-13.
- Wodick R., Steininger K., Zenner S. The biological treatment of articular affections - results of a study conducted with 498 patients // Biologische Medizin. - 1993; 3: 127-35.
- Hieber F. Intra-articular treatment of osteoarthritis and post-traumatic arthralgia with Zeel // Fortschritte der Medizin. - 1971; 89 (18): 778-80.
- Jäggi R., Würgler U., Grandjean F. et al. Dual inhibition of 5-lipoxygenase/ cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability // Inflamm. Res. - 2004; 53 (4): 150-7.
- Birnesser H., Stolt P. The homeopathic preparation Zeel comp. N: A review of the molecular and clinical data // Explore (NY). - 2007; 3 (1): 16-22.
- Tunon H., Olavsdotter C., Bohlin L. Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis // J. Ethnopharmacol. - 1995; 48: 61-76.
- Basini G., Santini S., Bussolati S. et al. Sanguinarine inhibits VEGF-induced Akt phosphorylation // Ann. N. Y. Acad. Sci. - 2007; 1095: 371-6.
- Basini G., Bussolati S., Santini S. et al. Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix // Biofactors. - 2007; 29 (1): 11-8.
- Schmolz M. Transforming Growth Factor beta (TGF-ß): eine neue Regelstrecke für antiphlogistische Therapien? // Biol. Med. - 2000; 29 (1): 31-4.
- Schmolz M., Heine H. Homöopathische Substanzen aus der antihomotoxischen Medizin modulieren die Synthese von TGF-ß1 in menschlichen Vollblutkulturen // Biol. Med. - 2001; 30 (2): 61-5.
- Stancikova M., Bély M., Svik K. et al. Effects of Zeel comp. on experimental osteoarthritis in rabbit knee // Rheumatologia. - 1999; 13 (3): 101-8.
- Weh L., Fröschle G. Incubation in preparations as a means of influencing cartilage mechanics: a mechanical study // Biol. Therapy. - 1990; 8 (4): 91-3.
- Haseeb A., Haggi T. Immunopathogenesis of osteoarthritis // Clin. Immunol. - 2013; 146 (3): 185-96.
- Bonnet C., Walsh D. Osteoarthritis, angiogenesis and inflammation // Rheumatology. - 2005; 44: 7-16.
- Malemud C. Anti-cytokine therapy for osteoarthritis // Drugs Aging. - 2010; 27 (2): 95-115.
- Fernadendes J., Materl-Pelletier J., Pelletier J. The role of cytokines in osteoarthritis pathophysiology // Biorheology. - 2002; 39 (1-2): 237-46.
- Pearle A., Scanzello C., George S. et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis // Osteoarthritis Cartilage. - 2007; 15 (5): 516-23.
- Walsh D., Pearson C. Angiogenesis in the pathogenesis of inflammatory joint and lung diseases // Arthritis Res. - 2001; 3: 147-52.
- Mentlein R., Pufe T. New functions of angiogenic peptides in osteoarthritic cartilage // Curr. Rheumatol. Rev. - 2005; 1: 37-45.
- Vane J., Botting R. Anti-inflammatory drugs and their mechanism of action // Inflamm. Res. - 1998; 47 (Suppl. 2): 78-87.
- Park J., Pillinger M., Abramson S. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases // Clin. Immunol. - 2006; 119 (3): 229-40.
- Giuliano F., Warner T. Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems // J. Pharmacol. Exp. Ther. - 2002; 303 (3): 1001-6.
- Kawabata A. Prostaglandin E2 and pain - an update // Biol. Pharm. Bull. -2011; 34 (8): 1170-3.
- Adatia A., Rainsford K., Kean W. Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy // J. Pharm. Pharmacol. - 2012; 64 (5): 617-25.
- Pountos I., Georgouli T., Bird H. et al. Nonsteroidal anti-inflammatory drugs: prostaglandins, indications and side-effects // IJICMR. - 2011; 3: 19-27.
- Heller A., Koch T. et al. Lipid mediators in inflammatory disorders // Drugs. - 1998; 55 (4): 487-96.
- Leone S., Ottani A., Bertolini A. Dual acting anti-inflammatory drugs // Curr. Top Med. Chem. - 2007; 7 (3): 265-75.
- Espanha M. Articular cartilage: structure and histochemical composition // Acta Reumatol. Port. - 2010; 35 (5): 424-33.
- Martel-Pelletier J., Boileau C., Pelletier J. et al. Cartilage in normal and osteoarthritis conditions // Best Pract. Res. Clin. Rheumatol. - 2008; 22 (2): 351-84.
- Aigner T., Soeder S., Haag J. IL-1 ß and BMPs - interactive players of cartilage matrix degradation and regeneration // Eur. Cell. Mater. - 2006; 12: 49-56.
- Yasuda T., Poole A. A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway // Arthritis Rheum. - 2002; 46: 138-48.
- Lozada C., del Rio E., Reitberg D. et al. Risk-benefit of co-administerd Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections in patients with moderate-to-severe pain associated with OA of the knee (OAK) // Ann. Rheum. Dis. - 2015; 74 (Suppl. 2): Abstract THU0441.
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