THE CLINICAL AND PATHOPHYSIOLOGICAL FEATURES OF ASTHMA-CHRONIC OBSTRUCTIVE PULMONARY DISEASE OVERLAP SYNDROME


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

In clinical practice, asthma and chronic obstructive pulmonary disease (COPD) are easily distinguishable; however, the asthma-COPD overlap syndrome (OS) in a patient causes both diagnostic and therapeutic challenges. The phenotype of the asthma-COPD OS is characterized by a worse prognosis than that of isolated diseases of asthma or COPD. OS is characterized by a concurrence of eosinophilic and neutrophilic inflammation in the respiratory tract, which is accompanied by obvious obstruction of the distal bronchi and bronchospasm. Patients with OS are a population different from those with asthma or COPD; and the identification of such persons into a special group is justified and appropriate in the context of pathophysiology, clinical presentations, and therapy.

Full Text

Restricted Access

About the authors

Zh. Mironova

Acad. I.P. Pavlov First Saint Petersburg State Medical University

Email: zhanmir@mail.ru
Professor MD

E. Vsevolodskaya

Acad. I.P. Pavlov First Saint Petersburg State Medical University

V. Belash

Acad. I.P. Pavlov First Saint Petersburg State Medical University

V. Trofimov

Acad. I.P. Pavlov First Saint Petersburg State Medical University

Professor MD

A. Ulitina

Acad. I.P. Pavlov First Saint Petersburg State Medical University

Candidate of Medical Sciences

S. Pchelina

Acad. I.P. Pavlov First Saint Petersburg State Medical University

M. Dubina

Acad. I.P. Pavlov First Saint Petersburg State Medical University

Professor MD, Academician of the Russian Academy of Sciences

S. Gorbunkov

Acad. I.P. Pavlov First Saint Petersburg State Medical University

Candidate of Medical Sciences

A. Akopov

Acad. I.P. Pavlov First Saint Petersburg State Medical University

Professor MD

References

  1. Menezes A., de Oca M., Perez-Padilla R. et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma // Chest. - 2014; 145: 297-304.
  2. Chung J., Ae Kong K., Lee J. et al. Characteristics and self-rated health of overlap syndrome // Int. J. COPD. - 2014; 9: 795-804.
  3. Kelly A., Bowen H., Jee Y. et al. The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases // J. Allergy Clin. Immunol. - 2008; 121 (1): 203.
  4. Pleasants R., Ohar J., Croft J. et al. Chronic obstructive pulmonary disease and asthma: patient characteristics and health impairment // COPD. - 2014; 11: 256-66.
  5. Sharma S., Chhabra D., Kho A. et al. The genomic origins of asthma // Thorax. - 2014; 69 (5): 481-7.
  6. Galban C., Han M., Boes J. et al. Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression // Nat. Med. - 2012; 18 (11): 1711-5.
  7. Soler-Cataluna J., Cosio B., Izquierdo J. et al. Consensus document on the overlap phenotype COPD-asthma in COPD // Arch. Bronconeumol. - 2012; 48 (9): 331-7.
  8. Contoli M., Baraldo S., Marku B. et al. Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up // J. Allergy Clin. Immunol. - 2010; 125 (4): 830-7.
  9. Soriano J., Davis K., Coleman B. et al. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom // Chest. - 2003; 124 (2): 474-81.
  10. Hardin M., Silverman E., Barr R. et al. The clinical features of the overlap between COPD and asthma // Respir. Res. - 2011; 12: 127.
  11. Miravitlles M., Soriano J., Ancochea J. et al. Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status // Respir. Med. - 2013; 107: 1053-60.
  12. Shaya F., Dongyi D., Akazawa M. et al. Burden of concomitant asthma and COPD in a Medicaid population // Chest. - 2008; 134 (1): 14-9.
  13. Weatherall M., Travers J., Shirtcliffe P. et al. Distinct clinical phenotypes of airways disease defined by cluster analysis // Eur. Respir. J. - 2009; 34 (4): 812-8.
  14. Guerra S. Overlap of asthma and chronic obstructive pulmonary disease // Curr. Opin. Pulm. Med. - 2005; 11 (1): 7-13.
  15. Buist A. Similarities and differences between asthma and chronic obstructive pulmonary disease: treatment and early outcomes // Eur. Respir. J. Suppl. - 2003; 39: 30-5.
  16. Kauppi P., Kupiainen H., Lindqvist A. et al. Overlap syndrome of asthma and COPD predicts low quality of life // J. Asthma. - 2011; 48 (3): 279-85.
  17. GINA-GOLD. Diagnosis of disease of chronic airflow limitation: asthma, COPD and asthma-COPD overlap syndrome (ACOS), 2014.
  18. Postma D., Reddel H., ten Hacken N. et al. Asthma and chronic obstructive pulmonary disease: similarities and differences // Clin. Chest. Med. - 2014; 35: 143-56.
  19. Louie S., Zeki A., Schivo M. et al. The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations // Expert Rev. Clin. Pharmacol. - 2013; 6: 197-219.
  20. Nakawah M., Hawkins C., Barbandi F. Asthma, chronic obstructive pulmonary disease (COPD), and the overlap syndrome // J. Am. Board. Fam. Med. - 2013; 26 (4): 470-7.
  21. Louie S., Zeki A., Schivo M. et al. The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations // Expert Rev. Clin. Pharmacol. - 2013; 6: 197-219.
  22. Agler А., Crystal R., Mezey J. et al. Differential expression of vitamin E and selenium-responsive genes by disease severity in chronic obstructive pulmonary disease // COPD. - 2013; 10: 450-8.
  23. Gibson P., Simpson J. The overlap syndrome of asthma and COPD: what are its features and how important is it? // Thorax. - 2009; 64: 728-35.
  24. Nakawah M., Hawkins C., Barbandi F. Asthma, chronic obstructive pulmonary disease (COPD), and the overlap syndrome // J. Am. Board. Fam. Med. - 2014; 26: 470-7.
  25. Papaiwannou A., Zarogoulidis P., Porpodis K. et al. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): current literature review // J. Thorac. Dis. - 2014; 6 (Suppl. 1): 146-51.
  26. Papaiwannou А., P., Porpodis K. et al. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): current literature review // Int. J. Pharm. - 2014; 461: 411-8.
  27. Iwamoto H., Gao J., Koskela J. et al. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap // Eur. Respir. J. - 2014; 43: 421-9.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies