ADVERSE REACTIONS TO BENZODIAZEPINE TRANQUILIZERS, IN PARTICULAR IN THE TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME
- Authors: Ivanova E.1,2, Ivashchenko D.3, Savchenko L.4, Bryun E.4,5, Sychev D.4
-
Affiliations:
- Young Scientists’ School of Pharmacogenetics, Pharmacogenomics, and Personalized Medicine, Russian Medical Academy of Continuing Education
- Mental Health Research Center
- Sector for Applied Problems of Personalized Medicine, Research Center
- Russian Medical Academy of Continuing Education
- Moscow Research and Practical Center for Narcology, Moscow Healthcare Department
- Issue: Vol 28, No 9 (2017)
- Pages: 9-13
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/116995
- ID: 116995
Cite item
Abstract
Full Text
![Restricted Access](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
About the authors
E. Ivanova
Young Scientists’ School of Pharmacogenetics, Pharmacogenomics, and Personalized Medicine, Russian Medical Academy of Continuing Education; Mental Health Research Center
Email: iva67856@gmail.com
D. Ivashchenko
Sector for Applied Problems of Personalized Medicine, Research Center
L. Savchenko
Russian Medical Academy of Continuing EducationCandidate of Medical Sciences
E. Bryun
Russian Medical Academy of Continuing Education; Moscow Research and Practical Center for Narcology, Moscow Healthcare DepartmentProfessor
D. Sychev
Russian Medical Academy of Continuing EducationProfessor MD, Corresponding Member of the Russia Academy of Sciences
References
- Ладыженский М.Я., Городничев А.В., Костюкова Е.Г. Бензодиазепиновые анксиолитики: востребованы ли они сегодня? // Современная терапия психических расстройств. - 2014; 2: 20-5.
- Осадший Ю.Ю., Вобленко Р.А., Арчаков Д.С. и др. Место бензодиазепинов в современной терапии психических расстройств (обзор доказательных исследований) // Современная терапия психических расстройств. - 2016; 1: 2-10.
- Olsen R., Sieghart W. International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update // Pharmacol. Rev. - 2008; 60 (3): 243-60.
- Saari T., Uusi-Oukari M., Ahonen, J. et al. Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology // Pharmacol. Rev. - 2011; 63 (1): 243-67.
- Belelli D. Extrasynaptic GABAA Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics // J. Neurosci. - 2005; 25 (50): 11513-20.
- Ernst M., Brauchart D., Boresch S. et al. Comparative modeling of GABAA receptors: Limits, insights, future developments // Neuroscience. - 2003; 119 (4): 933-43.
- Greenblatt D., Shader R., Divoll M. et al. Benzodiazepines: a summary of pharmacokinetic properties // Br. J. Clin. Pharmacol. - 1981; 11 (Suppl. 1): 11-6.
- Bird R., Makela E. Alcohol withdrawal: What is the benzodiazepine of choice? // Ann. Pharmacother. - 1994; 28 (1): 67-71.
- Kurko T., Saastamoinen L., Tähkäpää S. et al. Long-term use of benzodiazepines: Definitions, prevalence and usage patterns - a systematic review of register-based studies // Eur. Psychiatry. - 2015; 30 (8): 1037-47.
- Martins A., Giordani F., Rozenfeld S. Adverse drug events among adult inpatients: a meta-analysis of observational studies // J. Clin. Pharm. Ther. - 2014; 39 (6): 609-20.
- Jick H. Drugs - remarkably nontoxic // N. Engl. J. Med. - 1974; 291 (16): 824-8.
- Resar R., Rozich J., Simmonds T. et al. A trigger tool to identify adverse events in the intensive care unit // Jt. Comm. J. Qual. Patient. Saf. - 2006; 32 (10): 585-90.
- Назаренко Г.И., Клейменова Е.Б., Отделенов В.А. и др. Использование триггеров нежелательных событий для выявления побочных реакций при применении лекарственных средств в стационаре // Клин. фармакол. и тер. -2015; 4 (24): 55-62.
- Busto U., Naranjo C., Sellers E. Comparison of two recently published algorithms for assessing the probability of adverse drug reactions // Br. J. Clin. Pharmacol. - 1982; 13 (2): 223-7.
- Gallagher R., Kirkham J., Mason J. et al. Development and inter-rater reliability of the Liverpool adverse drug reaction causality assessment tool // PLoS One. - 2011; 6 (12): e28096.
- Chouinard G. Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound // J. Clin. Psychiatry. - 2004; 65 (Suppl. 5): 7-12.
- Pariente A., Dartigues J.-F., Benichou J. et al. Benzodiazepines and injurious falls in community dwelling elders // Drugs Aging. - 2008; 25 (1): 61-70.
- Uzun S., Kozumplik O., Jakovljevic M. et al. Side effects of treatment with benzodiazepines // Psychiatr. Danub. - 2010; 22 (1): 90-3.
- Arbanas G., Arbanas D., Dujam K. Adverse effects of benzodiazepines in psychiatric outpatients // Psychiatr. Danub. - 2009; 21 (1): 103-7.
- Nott D., Chandrasekar R., Enabi L. et al. Intra-arterial injection of temazepam in drug abusers // Eur. J. Vasc. Surg. - 1993; 7 (1): 87-9.
- Ruben S., Morrison C. Temazepam misuse in a group of injecting drug users // Br. J Addict. - 1992; 87 (10): 1387-92.
- De Witte P., Pinto E., Ansseau M. et al. Alcohol and withdrawal: From animal research to clinical issues // Neurosci. Biobehav. Rev. - 2003; 27 (3): 189-97.
- Sachdeva A., Choudhary M., Chandra M. Alcohol Withdrawal Syndrome: Benzodiazepines and Beyond // J. Clin. Diagn. Res. - 2015; 9 (9): VE01-VE07.
- Rubio G., Löpez-Mufloz F., Ponce G. et al. Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome // Pharmacopsychiatry. - 2010; 43 (7): 257-62.
- Addolorato G., Leggio L., Abenavoli L. et al. Baclofen in the treatment of alcohol withdrawal syndrome: A comparative study vs diazepam // Am. J. Med. -2006; 119 (3): 276.e13-276.e18.
- Lucht M., Kuehn K., Armbruster J. et al. Alcohol withdrawal treatment in intoxicated vs non-intoxicated patients: A controlled open-label study with tiapride / carbamazepine, clomethiazole and diazepam // Alcohol and Alcoholism. - 2003; 38 (2): 168-75.
- Martinotti G., di Nicola M., Frustaci A. et al. Pregabalin, tiapride and lorazepam in alcohol withdrawal syndrome: A multi-centre, randomized, singleblind comparison trial // Addiction. - 2010; 105 (2): 288-99.
- Myrick H., Malcolm R., Randall P. et al. A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal // Alcohol. Clin. Exp. Res. - 2009; 33 (9): 1582-8.
- Kumar C., Andrade C., Murthy P. A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal // J. Stud. Alcohol. Drugs. - 2009; 70 (3): 467-74.
- Ramanujam R., Lakshminarayana P., Gopalrao S. et al. A comparative study of the clinical efficacy and safety of Lorazepam and chlordiazepoxide in alcohol dependence syndrome // J. Clin. Diagn. Res. - 2015; 9 (3): FC10-FC13.
- Bonnet U., Lensing M., Specka M., et al. Comparison of two oral symptom-triggered pharmacological inpatient treatments of acute alcohol withdrawal: Clomethiazole vs. Clonazepam // Alcohol and Alcoholism. - 2011; 46 (1): 68-73.
- Crispo A., Daley M., Pepin J. et al. Comparison of clinical outcomes in nonintubated patients with severe alcohol withdrawal syndrome treated with continuous-infusion sedatives: Dexmedetomidine versus benzodiazepines // Pharmacotherapy. - 2014; 34 (9): 910-7.
- Sen S., Grgurich P., Tulolo A. et al. Evaluation of a Symptom-Triggered Benzodiazepine Protocol Utilizing SAS and CIWA-Ar Scoring for the Treatment of Alcohol Withdrawal Syndrome in the Critically Ill // Ann. Pharmacother. - 2016; 51 (2): 101-10.
- Wong A., Benedict N., Lohr B. et al. Management of benzodiazepine-resistant alcohol withdrawal across a healthcare system: Benzodiazepine dose-escalation with or without propofol // Drug. Alcohol. Depend. - 2015; 154: 296-9.
- Park H., Satoh H., Miki A. et al. Medications associated with falls in older people: systematic review of publications from a recent 5-year period // Eur. J. Clin. Pharmacol. - 2015; 71 (12): 1429-40.
- Chang C.-M., Chen M.-J., Tsai C.-Y. et al. Medical conditions and medications as risk factors of falls in the inpatient older people: a case-control study // Int. J. Geriatr. Psychiatry. - 2011; 26 (6): 602-7.
- Sgadari A., Lapane K., Mor V. et al. Oxidative and nonoxidative benzodiazepines and the risk of femur fracture. The Systematic Assessment of Geriatric Drug Use Via Epidemiology Study Group // J. Clin. Psychopharmacol. -2000; 20 (2): 234-9.
Supplementary files
![](/img/style/loading.gif)