Vol 28, No 9 (2017)

Alcoholic cardiomyopathy (ACMP) as a separate nosological unit is quite widespread in the world, which determines the relevance of this paper. The latter considers the mechanisms of cardiac damage and morphological changes in ACMP, its clinical features, and the principles of laboratory and instrumental diagnosis. It presents the results of a clinical examination of patients with ACMP.

Stress negatively affects the immune system, by potentiating tumor growth and worsening prognosis in cancer patients. Psychotherapy assists in dealing with this problem, including in normalizing hormonal balance and immunity.

The paper gives the results of comprehensive cardioneurological and neuropsychological examination in patients with acute ischemic stroke.

Hypertensive patients have a variety of changes at all structural and functional levels of the cerebrovascular system; the magnitude of the changes increases with weight loss.

The paper considers the issues of oral muscle relaxant treatment for nonspecific back pain.

The efficiency of carbetocin for the prevention of postpartum hemorrhage was evaluated in surrogate mothers, a high-risk group, during spontaneous labor.

The investigation has shown that CYP3A5*3 polymorphism has no significant impact on CYP3A4 activity and haloperidol equilibrium concentration in patients with alcohol dependence.

The authors revealed the advantages of rosuvastatin 40 mg/day over atorvastatin 80 mg/day in the 6-month combination therapy in patients with Q-wave myocardial infarction: in more promptly achieving targeted low-density lipoprotein levels and in normalizing C-reactive protein concentrations. There were no statistically significant differences in the improvement of intracardiac hemodynamic parameters (ejection fraction and stroke volume) and in the achievement of primary endpoints.

The paper considers the capabilities of laboratory platelet functional activity assessment with a Multiplate analyzer during acetylsalicylic acid therapy.

The paper gives data on the prevalence, pathogenesis, clinical features, diagnosis, and treatment of the most common form of diabetic neuropathy - distal symmetric sensorimotor polyneuropathy.

Uterine scar is one of the topical issues of the modern obstetrics. In the Russian Federation occurrence of Caesarean section is up to 22% of all delivery acts. At the same time the presence of uterine scar has reproductive toxicity, i.e. direct adverse impact on fertility in all phases. Argon plasma coagulation is one of the methods that improves uterine scar condition. A comprehensivemulticentrestudy of argon plasma coagulation impact on the reparative process of myometrium in cases of repeated caesarean sections has been conducted. Efficiency of this method to improve the uterine scar condition and the operative labor outcomeshas been proved.

The authors have defined the clinical value of a set of indicators, such as VEGF-A and VEGF-A/VEGF-R1, in mitral valve prolapse; the reduction of these can judge the severity of endothelial dysfunction associated with an increase in mitral regurgitation and with the frequency of clinically significant arrhythmias.

It has been found that a high first blood pressure (BP) measurement using the Korotkov method is determined by arterial smooth muscle function in accordance with the Frank-Starling mechanism. Therefore, unrepresentative first 2-3 blood pressure measurements are proposed to be excluded from a clinical analysis.