NEPHROTOXICITY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: MECHANISMS, CLINICAL PRESENTATIONS, PREVENTION


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Nonsteroidal anti-inflammatory drugs (NSAIDs) that are among the most popular classes of drugs are a leading cause of renal side effects. The mechanism of action of NSAIDs is associated with blockade of synthesis of renal vasodilator prostaglandins due to inactivation of the enzyme cyclooxygenase. Acute tubulointerstitial nephritis is the most common cause of NSAID-induced kidney injury. In addition, the risk of development and progression of chronic kidney disease has been reported. In this connection, it is necessary to conduct controlled randomized studies of renal complications caused by NSAIDs; the results of these studies will increase awareness of the problem discussed among physicians and pharmacists. It is necessary to strictly regulate the prescription of NSAIDs, to use both their optimal dosages and optimal use duration, and to assess the presence of risk factors for renal complications. To timely diagnose the nephrotoxicity of NSAIDs, a follow-up study of serum creatinine levels should be done calculating glomerular filtration rate, renal concentrating ability (Zimnitskys test), and complete urinalysis indices.

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作者简介

A. Dyadyk

Maksim Gorky Donetsk National Medical University

T. Kugler

Maksim Gorky Donetsk National Medical University

Email: kugler2@mail.ru

I. Tsyba

Maksim Gorky Donetsk National Medical University

V. Gnllltskaya

Maksim Gorky Donetsk National Medical University

A. Kaluga

Maksim Gorky Donetsk National Medical University

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