Psyllium as a lipid-lowering agent: results of a multicenter study


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

A total of 721 patients aged 19 to 91 years were examined and treated in a multicenter randomized prospective study. The use of psyllium (Mucofalk) in multitargeted therapy was justified in patients with hyperlipidemia, metabolic syndrome, and constipation. Mucofalk was proven to have a lipid-lowering effect in all patient groups; it was demonstrated that the drug could be co-administered with statins for synergistic action in patients at high and very high risk for cardiovascular diseases. Stool was normalized in the majority of patients long treated with Mucofalk. Drug discontinuation was not required in any patient. Twenty-four Mucofalk therapy reduced body mass index by an average of 4.759.80% without substantial dietary restrictions in the patients.

Full Text

Restricted Access

About the authors

S. Levchenko

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: sv_levchenko@list.ru
Candidate of Medical Sciences

I. Komissarenko

A.I. Evdokimov Moscow State University of Medicine and Dentistry

MD

References

  1. Информационный бюллетень №317, январь 2015 г. http://www.who.int/ mediacentre/factsheets/fs317/ru/
  2. Scandinavian Simvastatin Survival Study Group: Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study // Lancet. - 1994; 344: 1383-9.
  3. Saks F., Pfeffer M., Moye L. et al. The effects of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels // N. Engl. J. Med. - 1996; 335: 1001-9.
  4. The Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels // N. Engl. J. Med. - 1998; 339: 1349-57.
  5. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomized placebo-controlled trial // Lancet. - 2002; 360: 7-22.
  6. Sever P., Dahlof B., Poulter N. et al. for the ASCOT investigators. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Arm (ASCOT-LLA): a multicentre randomized controlled trial // Lancet. - 2003; 361: 1149-58.
  7. Руководство по кардиологии. Уч. пос. в 3 т. Под ред. Г.И. Сторожакова, А.А. Горбаченкова. Т. 1 / М.: ГЭОТАР-Медиа, 2008; 672 с.
  8. Диагностика и коррекция липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации РКО, V пересм., Москва // Рос. кардиол журн. - 2012; 4S1 (96): 2-32.
  9. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomized placebo-controlled trial // Lancet. - 2002; 360: 7-22.
  10. Shepherd L., Blauw G., Murphy M. et al. PROSPER study group. PROspectiveStudy of pravastatin in the elderly at risk. Pravastatin in Elderly individuals at Risk vascular disease (PROSPER): a randomised controlled trial // Lancet. - 2002; 360: 1623-30.
  11. Amarenco P., Bogousslavsky J., Amarenco P. et al. High-dose atorvastatin after stroke or transient ischemic attack // N. Engl. J. Med. - 2006; 355: 549-59.
  12. Colhoun H., Betteridge D., Durrington P. et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomized placebo-controlled trial // Lancet. - 2004; 364: 685-96.
  13. Kotseva K., Wood D., De Backer G. et al. EUROASPIRE Study Group. EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries // Eur. J. Cardiovasc. Prev. Rehabil. - 2009; 16 (2): 121-37.
  14. Сусеков А.В., Зубарева М.Ю., Деев А.Д. и др. Основные результаты Московского Исследования по Статинам (Moscow Statin Survey, MSS) // Сердце. - 2006; 6: 324-8.
  15. Шальнова С.А., Деев Л.Д. Уроки исследования ОСКАР - эпидемиология и особенности терапии пациентов высокого риска в реальной клинической практике 2005-2006 гг. // Кардиоваск. тер. и проф. - 2007; 6 (1): 47-53.
  16. Лукина Ю.В., Полянская Ю.Н., Толпыгина С.Н. и др. Изучение приверженности лечению статинами у пациентов с хронической ишемической сердца и соответствия гиполипидемической терапии клиническим рекомендациям(по данным регистра ПРОГНОЗ ИБС) // Профилакт. мед. -2014; 4: 39-43.
  17. Комиссаренко И.А., Левченко С.В., Сильвестрова С.Ю. и др. Терапия при дивертикулярной болезни и гиперхолестеринемии // Врач. - 2012; 4: 102-7.
  18. Комиссаренко И.А., Левченко С.В., Гудкова Р.Б. и др. Эффекты длительного применения псиллиума при лечении больных дивертикулярной болезнью толстой кишки // Клин. перспективы гастроэнтерол, гепатол. - 2014; 3: 29-36.
  19. Маевская Е.А., Маев И.В., Кучерявый Ю.А. и др. Оценка влияния лактулозы или пищевых волокон на динамику показателей липидного профиля у пациентов с функциональным запором и неалкогольным стеатогепатитом // Лечащий врач. - 2016; 4: 117-24.
  20. Свистунов А.А., Осадчук М.А., Буторова Л.И. и др. Синдром хронического запора в практике терапевта: особенности терапии при сочетанной патологии // Тер. арх. - 2017; 4: 69-74.
  21. Национальные рекомендации по кардиоваскулярной профилактике // Кардиоваск. тер. и профилакт. (Прил. 2). - 2011; 10 (6): 1-64.
  22. Lacy B., Mearin F., Chang L. et al. Bowel Disorders // Gastroenterology. -2016; 150: 1393-407.
  23. Hubacek J. et al. FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study // Physiological research: Academia Scientiarum Bohemoslovaca. - 2011; 60 (1): 175.
  24. Kuulasmaa K. et al. Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations // Lancet. - 2000; 355 (9205): 675-87.
  25. Ардатская М.Д. Клиническое применение пищевых волокон. Метод. пособие / М.: 4ТЕ Арт, 2010; 48 с.
  26. Wang Z., Zuberi A., Zhang X. et al. Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet // Metabolism. - 2007; 56 (12): 1635-42.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies