POLYMORPHIC VARIANTS IN THE CYP3A4 GENE, CYSTIC FIBROSIS, AND THE RISK OF ADVERSE REACTIONS TO ANTIBACTERIAL THERAPY IN CHILDREN


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Abstract

Chronic pulmonary infection is a consequence of impaired mucociliary clearance in cystic fibrosis (CF). Patients with CF receive long-term cycles of high-dose antibacterial therapy (ABT). A study of the causes of antibiotic resistance and adverse reactions (ARs) is promising in these patients. The impact of polymorphic variants in the CYP3A4 gene on the risk of ARs during ABT and on the predisposition to gram-negative infection was investigated in children with CF.

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About the authors

O. Novoselova

Research Center of Medical Genetics; N.F. Filatov City Children's Hospital Thirteenth

E. Kondratyeva

Research Center of Medical Genetics

N. Petrova

Research Center of Medical Genetics

R. Bikanov

Research Center of Medical Genetics

R. Zinchenko

Research Center of Medical Genetics; N.I. Pirogov Russian National Research Medical Universit

Email: lgnovoselova@gmail.com

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