Successful treatment for decompensated lactic acidosis in a child after high-dose chemotherapy


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Abstract

The paper describes a case of successful combination intensive care of a child with os-teosarcoma, who had received drug treatment with high-dose methotrexate, which was compli-cated by severe sepsis with multiple organ failure, anuria, decompensated lactic acidosis, and severe hemodynamic instability. Extracorporeal detoxification was used along with medical treatments.

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About the authors

A. Sotnikov

N.N. Blokhin National Medical Research Center of Oncology

MD

E. Gromova

N.N. Blokhin National Medical Research Center of Oncology

MD

O. Petina

N.N. Blokhin National Medical Research Center of Oncology

References

  1. Smeland S., Bruland O., Hjorth L. Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum flow up of 4 years // Acta Orthop. - 2011; 82 (2): 211-6. D0I:10.3109/17453674.2011. 566141.
  2. Семенова А.И. Саркома Юинга: характеристика заболевания, особенности диагностики, лечебная тактика // Практ. онкология. - 2010; 11 (1): 45-52.
  3. Иванова Н.М., Савлаев К.Ф., Шварова А.В. и др. Предварительные результаты высокодозной терапии метотрексатом остеосаркомы у детей // Детская онкология. - 2006; 4: 30-5.
  4. Мачак Г.Н., Соколовский В.А., Соловьев Ю.Н. и др. Роль предоперационной химиотерапии в органосохраняющем лечении остеосарком конечностей // Вместе против рака. - 2007; 3-4: 9-16.
  5. Dotan A., Dadia S., Bickels J. et al. Expandable endoprosthesis for limb-sparing surgery in children: long-term results // J. Child Orthop. - 2010; 4 (5): 391-400.
  6. Ferrari S., Bertoni F., Mercuri M. et al. Predictive factors of disease-free survival for non-metastatic osteosarcoma of the extremity: an analysis of 300 patients treated at the Rizzoli Institute // Ann. Oncol. - 2001; 12: 1145-50.
  7. Lewis I., Nooij M., Whelan J. et al. Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup // J. Natl. Cancer Inst. - 2007; 99 (2): 112-28.
  8. Gunnerson K., Saul M., Kellum J. Lactic versus nonlactic metabolic acidosis: outcomes in critically ill patients // Crit. Care. - 2003; 7: 17.
  9. Shahpori R., Stelfox H. Occurence and adverse effect on outcome of hyperlactatemia in the critically ill // Crit. Care. - 2009; 13: R90.
  10. Ruiz J., Singh A., Hart P. Type B Lactic Acidosis Secondary to Malignancy: Case Report, Review of Published Cases, Insights into Pathogenesis, and Prospects for Therapy // Sci. World J. - 2011; 11: 1316-24.
  11. Svahn J., Schiaffino M., Caruso U. et al. Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy // J. Pediatr. Hematol. Oncol. -2003; 25: 965-8.
  12. Manuel B., Suresh V., Saphwat E. Refractory metabolic acidosis in small cell cancer of the lung // South. Med. J. - 2006; 99: 782-3.
  13. de Groot R., Sprenger R., Imholz A. et al. Type B lactic acidosis in solid malignancies // Neth. J. Med. - 2011; 69: 120-3.
  14. Luft F. Lactic Acidosis Update for Critical Care Clinicians // J. Am. Soc. Naphrol. - 2001; 12: 15-9.
  15. Levraut J., Ciebiera J., Jambou P. et al. Effect of continuous venovenous hemofiltration with dialysis on lactate clearance in critically ill patients // Crit. Care Med. - 1997; 25 (1): 58-62.
  16. Honore P., Spapen H. Prognosis of extremely severe lactic acidosis in metformin-treated patients with septic shock: continuous renal replacement therapy in the spotlight! // Crit. Care. - 2016; 20: 127.
  17. Prikis, M., Bhasin, V., Young, M. et al. Sustained low-efficiency dialysis as a treatment modality in a patient with lymphoma-associated lactic acidosis // Nephrol. Dial. Transplant. - 2007; 22: 2383-5.
  18. Nguen H., Rivers E., Knoblich B. et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock // Crit. Care Med. - 2004; 32 (8): 1637-42.

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